Literature DB >> 10196343

Immunization with a live, attenuated simian immunodeficiency virus vaccine leads to restriction of viral diversity in Rhesus macaques not protected from pathogenic challenge.

D L Sodora1, K E Sheridan, P A Marx, R I Connor.   

Abstract

Rhesus macaques immunized with simian immunodeficiency virus SIVmac239Deltanef but not protected from SIVmac251 challenge were studied to determine the genetic and biological characteristics of the breakthrough viruses. Assessment of SIV genetic diversity (env V1-V2) revealed a reduction in the number of viral species in the immunized, unprotected macaques, compared to the number in nonimmunized controls. However, no evidence for selection of a specific V1-V2 genotype was observed, and biologically cloned isolates from the animals with breakthrough virus were similar with respect to replication kinetics and coreceptor use in vitro.

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Year:  1999        PMID： 10196343      PMCID： PMC104226     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Live attenuated simian immunodeficiency virus prevents super-infection by cloned SIVmac251 in cynomolgus monkeys.

Authors:  F Titti; L Sernicola; A Geraci; G Panzini; S Di Fabio; R Belli; F Monardo; A Borsetti; M T Maggiorella; M Koanga-Mogtomo; F Corrias; R Zamarchi; A Amadori; L Chieco-Bianchi; P Verani
Journal:  J Gen Virol       Date:  1997-10       Impact factor: 3.891

2.  Variation in simian immunodeficiency virus env is confined to V1 and V4 during progression to simian AIDS.

Authors:  J Overbaugh; L M Rudensey; M D Papenhausen; R E Benveniste; W R Morton
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

3.  Selective quasispecies transmission after systemic or mucosal exposure of macaques to simian immunodeficiency virus.

Authors:  O Neildez; R Le Grand; P Caufour; B Vaslin; A Chéret; F Matheux; F Théodoro; P Roques; D Dormont
Journal:  Virology       Date:  1998-03-30       Impact factor: 3.616

4.  Expression cloning of new receptors used by simian and human immunodeficiency viruses.

Authors:  H K Deng; D Unutmaz; V N KewalRamani; D R Littman
Journal:  Nature       Date:  1997-07-17       Impact factor: 49.962

5.  A genetic and viral load analysis of the simian immunodeficiency virus during the acute phase in macaques inoculated by the vaginal route.

Authors:  D L Sodora; F Lee; P J Dailey; P A Marx
Journal:  AIDS Res Hum Retroviruses       Date:  1998-01-20       Impact factor: 2.205

6.  Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses.

Authors:  J Rucker; A L Edinger; M Sharron; M Samson; B Lee; J F Berson; Y Yi; B Margulies; R G Collman; B J Doranz; M Parmentier; R W Doms
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

7.  Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene.

Authors:  M D Daniel; F Kirchhoff; S C Czajak; P K Sehgal; R C Desrosiers
Journal:  Science       Date:  1992-12-18       Impact factor: 47.728

8.  Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine.

Authors:  R I Connor; D C Montefiori; J M Binley; J P Moore; S Bonhoeffer; A Gettie; E A Fenamore; K E Sheridan; D D Ho; P J Dailey; P A Marx
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

9.  Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.

Authors:  M L Marthas; C J Miller; S Sutjipto; J Higgins; J Torten; B L Lohman; R E Unger; R A Ramos; H Kiyono; J R McGhee
Journal:  J Med Primatol       Date:  1992 Feb-May       Impact factor: 0.667

10.  STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.

Authors:  F Liao; G Alkhatib; K W Peden; G Sharma; E A Berger; J M Farber
Journal:  J Exp Med       Date:  1997-06-02       Impact factor: 14.307
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  2 in total

1.  The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cellsand T cells.

Authors:  D Messmer; R Ignatius; C Santisteban; R M Steinman; M Pope
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

2.  In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail.

Authors:  P N Fultz; P J Vance; M J Endres; B Tao; J D Dvorin; I C Davis; J D Lifson; D C Montefiori; M Marsh; M H Malim; J A Hoxie
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103
  2 in total

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