Literature DB >> 1431940

Brominated polyacetylenic acids from the marine sponge Xestospongia muta: inhibitors of HIV protease.

A D Patil1, W C Kokke, S Cochran, T A Francis, T Tomszek, J W Westley.   

Abstract

The EtOAc extract of the sponge Xestospongia muta collected in Colombus Island, Bahamas, yielded eleven straight-chain unsaturated, polyacetylenic, brominated acids, seven of which were identified on the basis of spectral data, including the unknown acids 2-7. These acetylenic acids are the first known examples that have been shown to inhibit HIV protease, a critical enzyme in the replication of human immunodeficiency virus.

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Year:  1992        PMID： 1431940     DOI： 10.1021/np50087a002

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

1.  Unusual C21 linear polyacetylenic alcohols from an Atlantic ascidian.

Authors:  Margherita Gavagnin; Francesco Castelluccio; Angelo Antonelli; Josè Templado; Guido Cimino
Journal:  Lipids       Date:  2004-07       Impact factor: 1.880

2.  The distribution of brominated long-chain fatty acids in sponge and symbiont cell types from the tropical marine sponge Amphimedon terpenensis.

Authors:  M J Garson; M P Zimmermann; C N Battershill; J L Holden; P T Murphy
Journal:  Lipids       Date:  1994-07       Impact factor: 1.880

Review 3.  Biosynthesis and function of polyacetylenes and allied natural products.

Authors:  Robert E Minto; Brenda J Blacklock
Journal:  Prog Lipid Res       Date:  2008-03-13       Impact factor: 16.195

4.  Isolation of brominated long-chain fatty acids from the phospholipids of the tropical marine sponge Amphimedon terpenensis.

Authors:  M J Garson; M P Zimmermann; M Hoberg; R M Larsen; C N Battershill; P T Murphy
Journal:  Lipids       Date:  1993-11       Impact factor: 1.880

5.  Antibacterial secondary metabolites from the cave sponge Xestospongia sp.

Authors:  Sridevi Ankisetty; Marc Slattery
Journal:  Mar Drugs       Date:  2012-05-07       Impact factor: 6.085

6.  Sponge holobionts shift their prokaryotic communities and antimicrobial activity from shallow to lower mesophotic depths.

Authors:  Anak Agung Gede Indraningrat; Georg Steinert; Leontine E Becking; Benjamin Mueller; Jasper M de Goeij; Hauke Smidt; Detmer Sipkema
Journal:  Antonie Van Leeuwenhoek       Date:  2022-08-23       Impact factor: 2.158

7.  Cytotoxic Compounds from the Saudi Red Sea Sponge Xestospongia testudinaria.

Authors:  Ali A El-Gamal; Shaza M Al-Massarani; Lamiaa A Shaala; Abdulrahman M Alahdald; Mansour S Al-Said; Abdelkader E Ashour; Ashok Kumar; Maged S Abdel-Kader; Wael M Abdel-Mageed; Diaa T A Youssef
Journal:  Mar Drugs       Date:  2016-04-26       Impact factor: 5.118

8.  Influence of Geographical Location on the Metabolic Production of Giant Barrel Sponges (Xestospongia spp.) Revealed by Metabolomics Tools.

Authors:  Lina M Bayona; Gemma van Leeuwen; Özlem Erol; Thomas Swierts; Esther van der Ent; Nicole J de Voogd; Young Hae Choi
Journal:  ACS Omega       Date:  2020-05-21

9.  Trait-Based Comparison of Coral and Sponge Microbiomes.

Authors:  Cara L Fiore; Jessica K Jarett; Georg Steinert; Michael P Lesser
Journal:  Sci Rep       Date:  2020-02-11       Impact factor: 4.379
  9 in total

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