Literature DB >> 1429227

Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures of reveromycins A, B, C and D.

H Koshino1, H Takahashi, H Osada, K Isono.   

Abstract

Reveromycins A, B, C and D are new group inhibitors of the mitogenic activity of epidermal growth factor (EGF), produced by Streptomyces sp. Reveromycins are novel polyketide type antibiotics which have two terminal carboxylic groups, a spiroketal, a succinate and a varied side chain in the molecule. Determination of their structures by chemical and spectroscopic methods, in particular NMR studies, is described.

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Year:  1992        PMID： 1429227     DOI： 10.7164/antibiotics.45.1420

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

1.  Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T.

Authors:  Shunji Takahashi; Shingo Nagano; Toshihiko Nogawa; Naoki Kanoh; Masakazu Uramoto; Makoto Kawatani; Takeshi Shimizu; Takeshi Miyazawa; Yoshitsugu Shiro; Hiroyuki Osada
Journal:  J Biol Chem       Date:  2014-09-25       Impact factor: 5.157

Review 2.  Chemical and biological studies of reveromycin A.

Authors:  Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2016-06-08       Impact factor: 2.649

3.  Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation.

Authors:  Shunji Takahashi; Atsushi Toyoda; Yasuyo Sekiyama; Hiroshi Takagi; Toshihiko Nogawa; Masakazu Uramoto; Ryuichiro Suzuki; Hiroyuki Koshino; Takuto Kumano; Suresh Panthee; Tohru Dairi; Jun Ishikawa; Haruo Ikeda; Yoshiyuki Sakaki; Hiroyuki Osada
Journal:  Nat Chem Biol       Date:  2011-06-05       Impact factor: 15.040

4.  Enantioselective total synthesis of spirofungins A and B.

Authors:  Michael T Crimmins; Elizabeth A O'Bryan
Journal:  Org Lett       Date:  2010-10-01       Impact factor: 6.005

5.  Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.

Authors:  Je-Tae Woo; Makoto Kawatani; Masanori Kato; Toshimasa Shinki; Takayuki Yonezawa; Naoki Kanoh; Hiroshi Nakagawa; Masamichi Takami; Kun Hyung Lee; Paula H Stern; Kazuo Nagai; Hiroyuki Osada
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-13       Impact factor: 11.205

6.  Structure and conformational analysis of spiroketals from 6-O-methyl-9(E)-hydroxyiminoerythronolide A.

Authors:  Ana Čikoš; Irena Ćaleta; Dinko Žiher; Mark B Vine; Ivaylo J Elenkov; Marko Dukši; Dubravka Gembarovski; Marina Ilijaš; Snježana Dragojević; Ivica Malnar; Sulejman Alihodžić
Journal:  Beilstein J Org Chem       Date:  2015-08-19       Impact factor: 2.883

7.  Reveromycins A and B from Streptomyces sp. 3-10: Antifungal Activity against Plant Pathogenic Fungi In vitro and in a Strawberry Food Model System.

Authors:  Ang Lyu; Hao Liu; Hongjie Che; Long Yang; Jing Zhang; Mingde Wu; Weidong Chen; Guoqing Li
Journal:  Front Microbiol       Date:  2017-04-03       Impact factor: 5.640

Review 8.  Asymmetric synthesis of naturally occurring spiroketals.

Authors:  B Rama Raju; Anil K Saikia
Journal:  Molecules       Date:  2008-08-28       Impact factor: 4.411
  8 in total

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