Literature DB >> 1428368

Effect of apocynin on the induction of ulcerative lesions in rat skin injected with tubercle bacteria.

B A Hart1, J G Elferink, P H Nibbering.   

Abstract

Apocynin is an effective and selective inhibitor of the neutrophil oxidative burst in vitro. Other neutrophil functions, tested in vitro, such as chemotaxis, exocytosis, phagocytosis and intracellular killing of bacteria are unaffected by apocynin. These properties make apocynin a potential anti-inflammatory agent in vivo. This was tested in WAG/Rij rats, injected intracutaneously with tubercle bacteria in oil (complete Freund's adjuvant). We show here that continuous administration of apocynin via the drinking water prevents the formation of ulcerative lesions in the inflamed skin. No effects on humoral and cellular immunity were observed after treatment with apocynin (between 1 and 100 micrograms/ml drinking water) measuring serum antibodies and delayed-type hypersensitivity, respectively.

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Year:  1992        PMID： 1428368     DOI： 10.1016/0192-0561(92)90138-b

Source DB:  PubMed          Journal:  Int J Immunopharmacol        ISSN： 0192-0561


  10 in total

1.  Toll-like receptor 4 deficiency causes pulmonary emphysema.

Authors:  Xuchen Zhang; Peiying Shan; Ge Jiang; Lauren Cohn; Patty J Lee
Journal:  J Clin Invest       Date:  2006-10-19       Impact factor: 14.808

2.  Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice.

Authors:  R B Muijsers; I van Ark; G Folkerts; A S Koster; A J van Oosterhout; D S Postma; F P Nijkamp
Journal:  Br J Pharmacol       Date:  2001-09       Impact factor: 8.739

Review 3.  Oxidative stress, Nox isoforms and complications of diabetes--potential targets for novel therapies.

Authors:  Mona Sedeek; Augusto C Montezano; Richard L Hebert; Stephen P Gray; Elyse Di Marco; Jay C Jha; Mark E Cooper; Karin Jandeleit-Dahm; Ernesto L Schiffrin; Jennifer L Wilkinson-Berka; Rhian M Touyz
Journal:  J Cardiovasc Transl Res       Date:  2012-06-19       Impact factor: 4.132

Review 4.  Oxidative stress in obstructive nephropathy.

Authors:  Amélie Dendooven; David A Ishola; Tri Q Nguyen; Dionne M Van der Giezen; Robbert Jan Kok; Roel Goldschmeding; Jaap A Joles
Journal:  Int J Exp Pathol       Date:  2010-08-27       Impact factor: 1.925

5.  Apocynin inhibits peroxynitrite formation by murine macrophages.

Authors:  R B Muijsers; E van Den Worm; G Folkerts; C J Beukelman; A S Koster; D S Postma; F P Nijkamp
Journal:  Br J Pharmacol       Date:  2000-06       Impact factor: 8.739

6.  Intermittent hypoxia has organ-specific effects on oxidative stress.

Authors:  Jonathan Jun; Vladimir Savransky; Ashika Nanayakkara; Shannon Bevans; Jianguo Li; Philip L Smith; Vsevolod Y Polotsky
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-08-13       Impact factor: 3.619

7.  Oral treatment with the NADPH oxidase antagonist apocynin mitigates clinical and pathological features of parkinsonism in the MPTP marmoset model.

Authors:  Ingrid H C H M Philippens; Jacqueline A Wubben; Bente Finsen; Bert A 't Hart
Journal:  J Neuroimmune Pharmacol       Date:  2013-03-17       Impact factor: 4.147

Review 8.  Experimental autoimmune encephalomyelitis in the common marmoset: a translationally relevant model for the cause and course of multiple sclerosis.

Authors:  Bert A 't Hart
Journal:  Primate Biol       Date:  2019-05-10

Review 9.  Apocynin, a low molecular oral treatment for neurodegenerative disease.

Authors:  Bert A 't Hart; Sjef Copray; Ingrid Philippens
Journal:  Biomed Res Int       Date:  2014-07-22       Impact factor: 3.411

Review 10.  Apocynin: molecular aptitudes.

Authors:  J Stefanska; R Pawliczak
Journal:  Mediators Inflamm       Date:  2008-12-02       Impact factor: 4.711
  10 in total

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