Literature DB >> 14264274

ANTI-DNA ANTIBODIES IN HYPERIMMUNIZED RABBITS.

C L CHRISTIAN, A R DESIMONE, J L ABRUZZO.   

Abstract

Complement-fixing anti-DNA antibodies were detected in a minority of sera of rabbits hyperimmunized with killed Gram-negative bacteria. The C'-fixing property of DNA was lost after DNase treatment. Preferential reactivity with denatured DNA was observed. The antisera reacted with DNA preparations derived from rabbit bone marrow and thymus, calf thymus, pneumococci, salmon sperm, and Escherichia coli. E. coli DNA was less effective than preparations of mammalian and salmon sperm DNA in fixation of C'. Inhibition of DNA C' fixation by nucleotides and nucleosides was observed. The bulk of anti-DNA activity was associated with the low molecular weight antibody fraction.

Entities:  

Keywords:  ANTIBODIES; BONE MARROW CELLS; CENTRIFUGATION; COMPLEMENT FIXATION TESTS; DIPLOCOCCUS PNEUMONIAE; DNA; DNA, BACTERIAL; ESCHERICHIA COLI; EXPERIMENTAL LAB STUDY; IMMUNIZATION; NUCLEOSIDES; NUCLEOTIDES; RABBITS; SPERMATOZOA; THYMUS GLAND

Mesh：

Substances：

Year:  1965        PMID： 14264274      PMCID： PMC2137977          DOI： 10.1084/jem.121.2.309

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  17 in total

1.  ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS AND MYASTHENIA GRAVIS WHICH REACT WITH THERMALLY DENATURED DNA-COATED BENTONITE.

Authors:  B C STURGILL; R R CARPENTER; A J STRAUSS; H C GOODMAN
Journal:  Proc Soc Exp Biol Med       Date:  1964-01

2.  Purine-specific antibodies which react with deoxvribonucleic acid (DNA).

Authors:  V P BUTLER; S M BEISER; B F ERLANGER; S W TANENBAUM; S COHEN; A BENDICH
Journal:  Proc Natl Acad Sci U S A       Date:  1962-09-15       Impact factor: 11.205

3.  Quantitative micro-complement fixation and its use in the study of antigenic structure by specific antigen-antibody inhibition.

Authors:  E WASSERMAN; L LEVINE
Journal:  J Immunol       Date:  1961-09       Impact factor: 5.422

4.  Passive cutaneous anaphylaxis reactions with a systemic lupus erythematosus serum factor and isolated DNA.

Authors:  H R DEICHER; H R HOLMAN; H G KUNKEL; Z OVARY
Journal:  J Immunol       Date:  1960-01       Impact factor: 5.422

5.  Affinity between the lupus erythematosus serum factor and cell nuclei and nucleoprotein.

Authors:  H R HOLMAN; H G KUNKEL
Journal:  Science       Date:  1957-07-26       Impact factor: 47.728

6.  Interaction of nuclei and globulin from lupus erythematosis serum demonstrated with fluorescent antibody.

Authors:  G J FRIOU; S C FINCH; K D DETRE
Journal:  J Immunol       Date:  1958-04       Impact factor: 5.422

7.  Complement fixation with cell nuclei and DNA in lupus erythematosus.

Authors:  W C ROBBINS; H R HOLMAN; H DEICHER; H G KUNKEL
Journal:  Proc Soc Exp Biol Med       Date:  1957-12

8.  SPECIFIC ANTIBODIES TO THERMALLY DENATURED DEOXYRIBONUCLEIC ACID OF PHAGE T4.

Authors:  L Levine; W T Murakami; H V Vunakis; L Grossman
Journal:  Proc Natl Acad Sci U S A       Date:  1960-08       Impact factor: 11.205

9.  PYRIMIDINE-SPECIFIC ANTIBODIES WHICH REACT WITH DEOXYRIBONUCLEIC ACID (DNA).

Authors:  S W Tanenbaum; S M Beiser
Journal:  Proc Natl Acad Sci U S A       Date:  1963-05       Impact factor: 11.205

10.  The induction of a rheumatoid factor-like substance in rabbits.

Authors:  J L ABRUZZO; C L CHRISTIAN
Journal:  J Exp Med       Date:  1961-11-01       Impact factor: 14.307
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  10 in total

1.  Features of the immune response to DNA in mice. I. Genetic control.

Authors:  G J Fournié; P H Lambert; P A Miescher
Journal:  Clin Exp Immunol       Date:  1976-10       Impact factor: 4.330

2.  Tissue antibodies in idiopathic autoimmune haemolytic anaemia.

Authors:  M A Blajchman
Journal:  Clin Exp Immunol       Date:  1971-05       Impact factor: 4.330

3.  Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus.

Authors:  E M Tan; P H Schur; R I Carr; H G Kunkel
Journal:  J Clin Invest       Date:  1966-11       Impact factor: 14.808

4.  The influence of thymic and bursal lymphoid systems in avian tuberculosis.

Authors:  N F Cheville; W D Richards
Journal:  Am J Pathol       Date:  1971-07       Impact factor: 4.307

Review 5.  Hyposensitization in asthma: a review.

Authors:  J O Warner
Journal:  J R Soc Med       Date:  1981-01       Impact factor: 5.344

Review 6.  Cellular and molecular aspects of immune system aging.

Authors:  D L Doggett; M P Chang; T Makinodan; B L Strehler
Journal:  Mol Cell Biochem       Date:  1981-07       Impact factor: 3.396

7.  Antinuclear antibodies in rabbit antisera.

Authors:  E V Barnett; J H Vaughan
Journal:  J Exp Med       Date:  1966-04-01       Impact factor: 14.307

8.  Antibodies to native and denatured deoxyribonucleic acid in systemic lupus erythematosus.

Authors:  R Arana; M Seligmann
Journal:  J Clin Invest       Date:  1967-11       Impact factor: 14.808

9.  Nuclear fluorescence employing antinucleoside immunoglobulins.

Authors:  W J Klein; S M Beiser; B F Erlanger
Journal:  J Exp Med       Date:  1967-01-01       Impact factor: 14.307

10.  Release of DNA in circulating blood and induction of anti-DNA antibodies after injection of bacterial lipopolysaccharides.

Authors:  G J Fournié; P H Lambert; P A Meischer
Journal:  J Exp Med       Date:  1974-11-01       Impact factor: 14.307
  10 in total

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