Literature DB >> 14263760

CYSTINURIA: EFFECT OF D-PENICILLAMINE ON PLASMA AND URINARY CYSTINE CONCENTRATIONS.

J C CRAWHALL, C J THOMPSON.   

Abstract

Administration of penicillamine reduced the concentration of cystine in the plasma and urine of patients with cystinuria; renal clearance of cystine, lysine, and arginine remained unchanged. Cysteine-penicillamine disulfide and penicillamine disulfide were detected in the plasma.

Entities:  

Keywords:  ARGININE; BLOOD; CYSTINURIA; DRUG THERAPY; LYSINE; PENICILLAMINE; SULFIDES; URINE

Mesh：

Substances：

Year:  1965        PMID： 14263760     DOI： 10.1126/science.147.3664.1459

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

Review 1.  Chemical basis for pharmacological and therapeutic actions of penicillamine.

Authors:  M Friedman
Journal:  Proc R Soc Med       Date:  1977

Review 2.  The management of cystinuria in 1976.

Authors:  A D Stephens
Journal:  Proc R Soc Med       Date:  1977

3.  Dissolution of Cystine Stones During d-Penicillamine Treatment of a Pregnant Patient with Cystinuria.

Authors:  J C Crawhall; E F Scowen; C J Thompson; R W Watts
Journal:  Br Med J       Date:  1967-04-22

4.  Cystinosis. Intracellular cystine depletion by aminothiols in vitro and in vivo.

Authors:  J G Thoene; R G Oshima; J C Crawhall; D L Olson; J A Schneider
Journal:  J Clin Invest       Date:  1976-07       Impact factor: 14.808

5.  An outline of D-penicillamine metabolism.

Authors:  D Perrett
Journal:  Proc R Soc Med       Date:  1977

6.  The renal clearance of amino acids in cystinuria.

Authors:  J C Crawhall; E F Scowen; C J Thompson; R W Watts
Journal:  J Clin Invest       Date:  1967-07       Impact factor: 14.808

7.  The metabolism and disposition of D-penicillamine in the DA-strain rat.

Authors:  A E Pilkington; R H Waring
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1988 Apr-Jun       Impact factor: 2.441
  7 in total

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