Literature DB >> 122676

An outline of D-penicillamine metabolism.

D Perrett1.   

Abstract

In a study using 14C-D-penicillamine in a normal subject only 50% of the D-penicillamine was absorbed from the gut. The major urinary metabolites are cysteine-penicillamine and penicillamine disulphide. S-methyl-D-penicillamine is the only biochemically transformed metabolite so far identified.

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Year:  1977        PMID: 122676      PMCID: PMC1543609     

Source DB:  PubMed          Journal:  Proc R Soc Med        ISSN: 0035-9157


  8 in total

1.  Effect of penicillamine on cystinuria.

Authors:  J C CRAWHALL; E F SCOWEN; R W WATTS
Journal:  Br Med J       Date:  1963-03-02

2.  [Pharmacokinetics and metabolism of D- and L-penicillamine. 1. Blood level, transport and protein binding].

Authors:  A Ruiz-Torres
Journal:  Arzneimittelforschung       Date:  1974-06

3.  [Pharmacokinetics and metabolism of D- and L-penicillamine. 3. Absorption, excretion, and metabolism].

Authors:  A Ruiz-Torres; I Kürten
Journal:  Arzneimittelforschung       Date:  1974-09

4.  [Pharmacokinetic studies on 14 C-labelled penicillamine].

Authors:  F Planas-Bohne
Journal:  Arzneimittelforschung       Date:  1972-09

5.  Studies with 35S-labelled DL-penicillamine in patients with Wilson's disease.

Authors:  K Gibbs; J M Walshe
Journal:  Q J Med       Date:  1971-04

6.  Transport of penicillamine across mucosa of the rat small intestine in vitro.

Authors:  M Wass; D F Evered
Journal:  Biochem Pharmacol       Date:  1970-04       Impact factor: 5.858

7.  Studies on D-penicillamine metabolism in cystinuria and rheumatoid arthritis: isolation of S-methyl-D-penicillamine.

Authors:  D Perrett; W Sneddon; A D Stephens
Journal:  Biochem Pharmacol       Date:  1976-02-01       Impact factor: 5.858

8.  CYSTINURIA: EFFECT OF D-PENICILLAMINE ON PLASMA AND URINARY CYSTINE CONCENTRATIONS.

Authors:  J C CRAWHALL; C J THOMPSON
Journal:  Science       Date:  1965-03-19       Impact factor: 47.728

  8 in total
  7 in total

1.  D-penicillamine metabolism: the role of transformation in blood plasma.

Authors:  D A Joyce; B R Murphy
Journal:  Agents Actions       Date:  1990-11

2.  Failure of oral thiomalate to act as an alternative to intramuscular gold in rheumatoid arthritis.

Authors:  S R Rudge; D Perrett; M Kelly
Journal:  Ann Rheum Dis       Date:  1988-03       Impact factor: 19.103

Review 3.  Induction of auto-immune syndromes by penicillamine therapy in rheumatoid arthritis and other diseases.

Authors:  I A Jaffe
Journal:  Springer Semin Immunopathol       Date:  1981

Review 4.  Clinical pharmacokinetics of D-penicillamine.

Authors:  P Netter; B Bannwarth; P Péré; A Nicolas
Journal:  Clin Pharmacokinet       Date:  1987-11       Impact factor: 6.447

5.  D-penicillamine metabolism in an in-vivo model of inflamed synovium.

Authors:  D A Joyce; M J Forrest; P M Brooks
Journal:  Agents Actions       Date:  1988-12

6.  Historical perspectives on penicillamine.

Authors:  L Fernandes; H Berry; E Hamilton
Journal:  J R Coll Physicians Lond       Date:  1980-04

7.  Hepatic drug-metabolizing enzymes and drug transporters in Wilson's disease patients with liver failure.

Authors:  Sylwia Szeląg-Pieniek; Stefan Oswald; Mariola Post; Joanna Łapczuk-Romańska; Marek Droździk; Mateusz Kurzawski
Journal:  Pharmacol Rep       Date:  2021-06-11       Impact factor: 3.024

  7 in total

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