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Literature DB >> 14228140

INHIBITION OF SYMPATHOMIMETIC EFFECTS ON THE HEART.

Abstract

The adrenaline beta-receptor blocking drug, pronethalol, and the sympathomimetic amines, (-)-ephedrine, (-)-amphetamine, dexamphetamine, (-)-Psi-ephedrine and tyramine, inhibited the sympathomimetic effects of butyrylcholine and tyramine on the guinea-pig isolated atrium. Being reversible and noncompetitive, this antagonism was unspecific and not due to blockade of adrenaline receptors, although pronethalol inhibited the effect of noradrenaline competitively.

Entities: Chemical Species

Keywords: AMPHETAMINE; DEXTRO AMPHETAMINE; EPHEDRINE; EXPERIMENTAL LAB STUDY; GUINEA PIGS; HEART; NOREPINEPHRINE; PHARMACOLOGY; PRONETHALOL; RECEPTORS, NEURAL; SYMPATHOLYTICS; SYMPATHOMIMETICS; TYRAMINE

Mesh：

Substances：

Year: 1964 PMID： 14228140 PMCID： PMC1704102 DOI： 10.1111/j.1476-5381.1964.tb01596.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

10 in total

6. Electrochemical aspects of physiological and pharmacological action in excitable cells. II. The action potential and excitation.

Authors: A M SHANES
Journal: Pharmacol Rev Date: 1958-06 Impact factor: 25.468

10. A COMPARISON OF THE ANTIFIBRILLATORY ACTIONS AND EFFECTS ON INTRACELLULAR CARDIAC POTENTIALS OF PRONETHALOL, DISOPYRAMIDE AND QUINIDINE.

Authors: A SEKIYA; E M VAUGHANWILLIAMS
Journal: Br J Pharmacol Chemother Date: 1963-12

10 in total

7 in total

INHIBITION OF SYMPATHOMIMETIC EFFECTS ON THE HEART.

1. MODIFICATION BY RESERPINE OF THE RESPONSE OF THE ATRIAL PACEMAKER TO SYMPATHOMIMETIC AMINES.

2. LOCAL ANAESTHETIC ACTIVITY OF THE BETA-RECEPTOR ANTAGONIST, PRONETHALOL.

3. The synpathomimetic effect of acetylcholine on the spleen of the cat.

4. Pharmacology of a new adrenergic beta-receptor-blocking compound (Nethalide).

5. Interactions of sympathomimetic drugs and their antagonists on the isolated atrium.

6. Electrochemical aspects of physiological and pharmacological action in excitable cells. II. The action potential and excitation.

7. [Experiments with acetylcholine, propionylcholine and butyrylcholine on isolated heart auricle preparation].

8. Antifibrillatory action.

9. Some quantitative uses of drug antagonists.

10. A COMPARISON OF THE ANTIFIBRILLATORY ACTIONS AND EFFECTS ON INTRACELLULAR CARDIAC POTENTIALS OF PRONETHALOL, DISOPYRAMIDE AND QUINIDINE.

1. Factors affecting the cerebrovascular response to noradrenaline in the dog.

2. The effect of propranolol on the response of the rat isolated heart to noradrenaline.

3. Antisympathomimetic and antifibrillatory effects of pronethalol and propranolol.

4. Modifications by propranolol of the response of isolated rabbit atria to endogenous and exogenous noradrenaline.

5. [Monoamine oxidase inhibition by beta-adrenolytic substances].

6. The effects of some beta-adrenoreceptor blocking drugs on the uptake and release of noradrenaline by the heart.

7. Influence of beta-adrenoceptor blocking agents on the turnover rate of cardiac and splenic noradrenaline in rats.