Literature DB >> 14221487

CLEFT PALATE IN THE MOUSE: A TERATOGENIC INDEX OF GLUCOCORTICOID POTENCY.

L PINSKY, A M DIGEORGE.   

Abstract

Clinically equivalent doses of hydrocortisone, prednisolone, and dexamethasone have progressively increasing teratogenic activity as judged by their ability to induce cleft palate in the offspring of pregnant mice treated with these drugs during the middle period of gestation. Mole for mole, dexamethasone is at least 300 times more teratogenic than hydrocortisone. The enhanced teratogenicity of dexamethasone probably does not result from its relatively decreased mineralocorticoid activity.

Entities:  

Keywords:  CLEFT PALATE; DESOXYCORTICOSTERONE; DEXAMETHASONE; EXPERIMENTAL LAB STUDY; HYDROCORTISONE TOXICOLOGY; MATERNAL-FETAL EXCHANGE; MICE; PREDNISOLONE; PREGNANCY; PREGNANCY, ANIMAL; TOXICOLOGIC REPORT

Mesh：

Substances：

Year:  1965        PMID： 14221487     DOI： 10.1126/science.147.3656.402

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  23 in total

1.  EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases.

Authors:  J N Hoes; J W G Jacobs; M Boers; D Boumpas; F Buttgereit; N Caeyers; E H Choy; M Cutolo; J A P Da Silva; G Esselens; L Guillevin; I Hafstrom; J R Kirwan; J Rovensky; A Russell; K G Saag; B Svensson; R Westhovens; H Zeidler; J W J Bijlsma
Journal:  Ann Rheum Dis       Date:  2007-07-27       Impact factor: 19.103

Review 2.  Environmental mechanisms of orofacial clefts.

Authors:  Michael A Garland; Kurt Reynolds; Chengji J Zhou
Journal:  Birth Defects Res       Date:  2020-10-30       Impact factor: 2.344

Review 3.  Pregnancy in systemic lupus erythematosus.

Authors:  C C Mok; R W Wong
Journal:  Postgrad Med J       Date:  2001-03       Impact factor: 2.401

Review 4.  Treatment of inflammatory rheumatic disorders in pregnancy: what are the safest treatment options?

Authors:  M Ostensen; R Ramsey-Goldman
Journal:  Drug Saf       Date:  1998-11       Impact factor: 5.606

5.  [Electrolytes of the blood and endometrial secretions of the cow following glucocorticoid therapy].

Authors:  M Ibrahim; P Guay; P Lamothe
Journal:  Can J Comp Med       Date:  1972-04

6.  A metabonomic approach to analyze the dexamethasone-induced cleft palate in mice.

Authors:  Jinglin Zhou; Bin Xu; Bing Shi; Jing Huang; Wei He; Shengjun Lu; Junjun Lu; Liying Xiao; Wei Li
Journal:  J Biomed Biotechnol       Date:  2010-08-10

7.  Teratogenicity screening in standardized chick embryo culture: effects of dexamethasone and diphenylhydantoin.

Authors:  P Kucera; M B Burnand
Journal:  Experientia       Date:  1988-10-15

Review 8.  Using corticosteroids during pregnancy. Are topical, inhaled, or systemic agents associated with risk?

Authors:  D Oren; I Nulman; M Makhija; S Ito; Gideon Koren
Journal:  Can Fam Physician       Date:  2004-08       Impact factor: 3.275

9.  Glucocorticoid-induced phospholipase A2-inhibitory proteins mediate glucocorticoid teratogenicity in vitro.

Authors:  C Gupta; M Katsumata; A S Goldman; R Herold; R Piddington
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

Review 10.  [Pregnancy and immunomodulatory therapy in multiple sclerosis patients].

Authors:  L A Hoffmann; T Kümpfel; I Heer; R Hohlfeld
Journal:  Nervenarzt       Date:  2006-06       Impact factor: 1.214
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.