Literature DB >> 14208575

CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS.

H L ENNIS, M LUBIN.   

Abstract

Cycloheximide and acetoxy-cycloheximide specifically inhibit protein synthesis in L-cells growing in suspension culture. In extracts of rat liver, the drugs inhibit transfer of amino acid from soluble RNA to polypeptide. Unlike puromycin, these drugs do not accelerate release of nascent polypeptide chains. The drugs have no effect on protein synthesis in extracts of Escherichia coli.

Entities:  

Keywords:  AMINO ACID METABOLISM; ANTIBIOTICS; ANTIMETABOLITES; EXPERIMENTAL LAB STUDY; L CELLS; LIVER EXTRACTS; PHARMACOLOGY; PROTEIN METABOLISM; RNA, SOLUBLE

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Year:  1964        PMID： 14208575     DOI： 10.1126/science.146.3650.1474

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  98 in total

Review 1.  Interaction of chlamydiae and host cells in vitro.

Authors:  J W Moulder
Journal:  Microbiol Rev       Date:  1991-03

2.  Influence of cycloheximide on the synthesis and utilization of amino acids in suspension cultures.

Authors:  J S Fletcher; H Beevers
Journal:  Plant Physiol       Date:  1971-09       Impact factor: 8.340

3.  Structural basis for inhibition of protein synthesis by emetine and cycloheximide based on an analogy between ipecac alkaloids and glutarimide antibiotics.

Authors:  A P Grollman
Journal:  Proc Natl Acad Sci U S A       Date:  1966-12       Impact factor: 11.205

4.  Determinism and divergence of apoptosis susceptibility in mammalian cells.

Authors:  Patrick D Bhola; Sanford M Simon
Journal:  J Cell Sci       Date:  2009-11-03       Impact factor: 5.285

5.  Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae.

Authors:  Bryce W Buchanan; Michael E Lloyd; Sarah M Engle; Eric M Rubenstein
Journal:  J Vis Exp       Date:  2016-04-18       Impact factor: 1.355

6.  Inadequacy of the eucaryote inhibitor cycloheximide in studies of protozoan grazing on bacteria at the freshwater-sediment interface.

Authors:  S C Tremaine; A L Mills
Journal:  Appl Environ Microbiol       Date:  1987-08       Impact factor: 4.792

7.  Protein synthesis by isolated etioplasts and chloroplasts from pea and wheat and the effects of chloramphenicol and cycloheximide.

Authors:  B J Reger; R M Smillie; R C Fuller
Journal:  Plant Physiol       Date:  1972-07       Impact factor: 8.340

8.  Growth inhibitory effects of large subunit ribosomal proteins in melanoma.

Authors:  Gregory R Kardos; Mu-Shui Dai; Gavin P Robertson
Journal:  Pigment Cell Melanoma Res       Date:  2014-06-16       Impact factor: 4.693

9.  [The influence of actinomycin D, puromycin, cycloheximide, chloramphenicol, and rifampicin on gamete formation in Acetabularia mediterranea].

Authors:  H U Koop
Journal:  Planta       Date:  1975-01       Impact factor: 4.116

10.  Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.

Authors:  Joseph D Racca; Yen-Shan Chen; Yanwu Yang; Nelson B Phillips; Michael A Weiss
Journal:  J Biol Chem       Date:  2016-08-30       Impact factor: 5.157
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