| Literature DB >> 14208196 |
A BONACCORSI, S GARATTINI, A JORI.
Abstract
Chlorpromazine induces in rats a marked and long-lasting hyperglycaemia which (a) is more marked at low than high room temperatures, (b) is inhibited by phentolamine but not by dibenamine, and (c) is prevented by adrenalectomy, by removal of the adrenal medullae and by treatment of the rats with reserpine. Other experimental results suggest that there is a correlation between the hyperglycaemia and the hypothermia induced by chlorpromazine and by its congeners. The hyperglycaemia seems to be the result of at least two factors: an activation of the adrenergic mechanisms and an impaired peripheral utilization of glucose.Entities:
Keywords: ADRENAL MEDULLA; ADRENALECTOMY; CHLORPROMAZINE TOXICOLOGY; DIBENAMINE; EXPERIMENTAL LAB STUDY; GLUCOSE METABOLISM; HYPERGLYCEMIA; INJECTIONS, INTRAPERITONEAL; PHARMACOLOGY; PHENTOLAMINE; RATS; RESERPINE; SYMPATHOLYTICS; TEMPERATURE; THIORIDAZINE; TRIFLUPROMAZINE
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Year: 1964 PMID： 14208196 PMCID： PMC1703947 DOI： 10.1111/j.1476-5381.1964.tb01570.x
Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826