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Literature DB >> 14208193

QUANTITATIVE COMPARISON BETWEEN OXYTOCIN AND FOUR RELATED NEUROHYPOPSIAL PEPTIDES ON THE HUMAN UTERUS IN SITU.

Abstract

Quantitative assays of four synthetic peptides related to oxytocin were carried out on the post partum human uterus in vivo by means of external tocography. The following activities (U/mg, means and standard errors) were found: isoleucine(8)-oxytocin 365+/-70, asparagine(4)-oxytocin 150+/-40, desamino(1)-oxytocin 1,030+/-300, serine(4)-isoleucine(8)-oxytocin 335+/-95. None of the conventional bioassay procedures proved to be fully reliable for predicting the oxytocic activity in man of peptides related to oxytocin. If the tocographically recorded effects of equipotent doses of the compounds are compared with those of oxytocin no qualitative differences can be observed.

Entities: Chemical Gene Species

Keywords: ASPARAGINE; BIOLOGICAL ASSAY; ISOLEUCINE; OXYTOCIN; PEPTIDES; PHARMACOLOGY; PITUITARY HORMONES, POSTERIOR; UTERUS

Mesh：

Substances：

Year: 1964 PMID： 14208193 PMCID： PMC1703946 DOI： 10.1111/j.1476-5381.1964.tb01577.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

12 in total

Review 2. [MEDICAL AND BIOLOGICAL ASPECTS OF PHARMACOLOGICAL WORKS WITH SYNTHETIC PEPTIDES OF THE NEUROHYPOPHYSIAL TYPE].

Authors: B BERDE; A CERLETTI
Journal: Klin Wochenschr Date: 1964-12-01

3. Deamino-1-phenylalanine-2-arginine-8-vasopressin: a peptide with highly selective antidiuretic activity.

Authors: E Stürmer; R L Huguenin; R A Boissonnas; B Berde
Journal: Experientia Date: 1965-10-15

3 in total

QUANTITATIVE COMPARISON BETWEEN OXYTOCIN AND FOUR RELATED NEUROHYPOPSIAL PEPTIDES ON THE HUMAN UTERUS IN SITU.

1. Effect of human pregnancy serum on avian depressor activities of oxytocin and desamino-oxytocin.

2. The synthesis and some pharmacological effects of serine-isoleucine-oxytocin, a probable neurohypophysial hormone.

3. Synthesis of desamino-desoxyoxytocin, a biologically active analogue of oxytocin.

4. Physiological and clinical aspects of uterine action.

5. The guard-ring tocodynamometer; absolute measurement of intra-amniotic pressure by a new instrument.

6. A simplified internal tocograph.

7. Effect of valyl-oxytocin on the human subject.

8. [Blood oxytocinase in pregnancy].

9. Quantative assays of oxytocic drugs on the human postpartum uterus.

10. Some pharmacological actions of four synthetic analogues of oxytocin.

1. (DESAMINO-ARGININE-VASOPRESSIN, AN ANALOGUE OF ARGININE-VASOPRESSIN WITH HIGH ANTIDIURETIC ACTIVITY.)

Review 2. [MEDICAL AND BIOLOGICAL ASPECTS OF PHARMACOLOGICAL WORKS WITH SYNTHETIC PEPTIDES OF THE NEUROHYPOPHYSIAL TYPE].

3. Deamino-1-phenylalanine-2-arginine-8-vasopressin: a peptide with highly selective antidiuretic activity.