Literature DB >> 14197563

STREPTOMYCINOID ANTIBIOTICS: SYNERGISM BY PUROMYCIN.

J R WHITE, H L WHITE.   

Abstract

Puromycin synergizes the lethal action of streptomycin and related antibiotics. This is interpreted to mean that puromycin action uncovers a sensitive site (or sites) on the 30S ribosome. The streptomycinoid antibiotics can then associate more readily with the ribosome and inhibit further synthesis of valid protein.

Entities:  

Keywords:  ANTIBIOTICS; CHLORAMPHENICOL; ESCHERICHIA COLI; EXPERIMENTAL LAB STUDY; KANAMYCIN; NEOMYCIN; PAROMOMYCIN; PHARMACOLOGY; PUROMYCIN; RIBOSOMES; STREPTOMYCIN; VIOMYCIN

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Substances：

Year:  1964        PMID： 14197563     DOI： 10.1126/science.146.3645.772

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Effects of production of abnormal proteins on the rate of killing of Escherichia coli by streptomycin.

Authors:  M A Wyka; A C St John
Journal:  Antimicrob Agents Chemother       Date:  1990-04       Impact factor: 5.191

2.  Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides.

Authors:  B D Davis; L L Chen; P C Tai
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

3.  Antibiotic inhibitors of the bacterial ribosome.

Authors:  B Weisblum; J Davies
Journal:  Bacteriol Rev       Date:  1968-12

Review 4.  Mechanism of bactericidal action of aminoglycosides.

Authors:  B D Davis
Journal:  Microbiol Rev       Date:  1987-09

5.  Inhibition of the incorporation of 14C-precursors in Mycobacterium smegmatis by antibiotics and chemotherapeutics.

Authors:  V Majtán
Journal:  Folia Microbiol (Praha)       Date:  1982       Impact factor: 2.099

6.  Phenotypic suppression in Escherichia coli by chloramphenicol and other reversible inhibitors of the ribosome.

Authors:  C Kirschmann; B D Davis
Journal:  J Bacteriol       Date:  1969-04       Impact factor: 3.490

7.  A study of rubidium accumulation in Euglena gracillis.

Authors:  M L Brenner; D N Maynard
Journal:  Plant Physiol       Date:  1966-10       Impact factor: 8.340

8.  Partial inhibition of polysomal ribosomes of Escherichia coli by streptomycin.

Authors:  B J Wallace; P C Tai; E L Herzog; B D Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1973-04       Impact factor: 11.205
  8 in total

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