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Literature DB >> 141798

Therapeutic studies with BCG, cyclophosphamide and surgery alone and in combination on the autochthonous mammary carcinoma of the rat.

Abstract

In a randomized study the effects of BCG, cyclophosphamide and surgery alone and in combination on the mammary carcinoma (induced by 7,12-dimethylbenz(a)anthracene) of the rat were investigated. Surgical excision of the tumours increased the survival time. Cyclophosphamide retarded growth of tumours and delayed the appearance of relapses compared to surgery. A single, intravenous injection of BCG (10(7) viable organisms) showed no statistically significant retardation of tumours. Immunotherapy with BCG could not increase the effectiveness of cyclophosphamide or surgery or their combination.

Entities: Chemical Disease Species

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Year: 1977 PMID： 141798 DOI： 10.1007/bf02571687

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

15 in total

1. [Comparative investigation of the chemotherapeutic action of N-oxide-mustard gas and other alkylating compounds in rat tumors].

Authors: P DANNEBERG; H DRUCKREY; K KAISER; H W LO; R MECKE; H A NIEPER; D SCHMAHL
Journal: Arzneimittelforschung Date: 1956-09

2. Introduction: animal models of immunotherapy of cancer.

Authors: H J Rapp
Journal: Natl Cancer Inst Monogr Date: 1973-12

Review 3. Active immunotherapy.

Authors: G Mathé
Journal: Adv Cancer Res Date: 1971 Impact factor: 6.242

4. Comparative study on the effects of surgery, chemotherapy, and immunotherapy, alone and in combination, on metastases of the 13762 mammary adenocarcinoma.

Authors: A E Bogden; H J Esber; D J Taylor; J H Gray
Journal: Cancer Res Date: 1974-07 Impact factor: 12.701

5. Facilitation of rat mammary tumour growth by BCG.

Authors: W F Piessens; F L Lachapelle; N Legros; J C Heuson
Journal: Nature Date: 1970-12-19 Impact factor: 49.962

6. [Synergistic therapeutic effect of adriamycin with 5-fluor-uracil, with prednisolon and with cyclophosphamide on chemically induced mammary cancer of the rat (author's transl)].

Authors: H H Fiebig; D Schmähl
Journal: Klin Wochenschr Date: 1977-05-01

Therapeutic studies with BCG, cyclophosphamide and surgery alone and in combination on the autochthonous mammary carcinoma of the rat.

1. [Comparative investigation of the chemotherapeutic action of N-oxide-mustard gas and other alkylating compounds in rat tumors].

2. Introduction: animal models of immunotherapy of cancer.

Review 3. Active immunotherapy.

4. Comparative study on the effects of surgery, chemotherapy, and immunotherapy, alone and in combination, on metastases of the 13762 mammary adenocarcinoma.

5. Facilitation of rat mammary tumour growth by BCG.

6. [Synergistic therapeutic effect of adriamycin with 5-fluor-uracil, with prednisolon and with cyclophosphamide on chemically induced mammary cancer of the rat (author's transl)].

7. An experimental screening for "systemic adjuvants of immunity" applicable in cancer immunotherapy.

8. [Studies in rats on immunosuppressive properties of cytostatics with special consideration of carcinogenic effect].

Review 9. Immunological factors which influence response to immunotherapy in malignant melanoma.

10. Active immunotherapy of L1210 leukaemia applied after the graft of tumour cells.

1. Chemotherapy studies in autochthonous rat tumors: hepatomas.

2. Chemotherapy studies in autochthonous rat tumors intestinal cancer.