Literature DB >> 1417826

Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1).

L Xiao1, P Celano, A R Mank, C Griffin, E W Jabs, A L Hawkins, R A Casero.   

Abstract

The super induction of spermidine/spermine N1-acetyltransferase (SSAT), has been implicated in the cytotoxic response of human solid tumors to the bis(ethyl)polyamines. The SSAT response is a phenotype specific response and is modulated at the level of increased steady-state mRNA levels and enzyme protein. The human genomic region (4,095 bases) containing the coding sequence of SSAT has been cloned and localized to the Xp22.1 region. Primer extension analysis indicates the transcription of SSAT starts 179 bases upstream from the translational start site and appears to be under the control of a "TATA-less" promoter. The availability of this human clone will facilitate the direct functional examination of the SSAT gene.

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Year:  1992        PMID： 1417826     DOI： 10.1016/0006-291x(92)90471-v

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

Review 1.  Heat shock protein 10 and signal transduction: a "capsula eburnea" of carcinogenesis?

Authors:  Anna M Czarnecka; Claudia Campanella; Giovanni Zummo; Francesco Cappello
Journal:  Cell Stress Chaperones       Date:  2006       Impact factor: 3.667

2.  Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells.

Authors:  Naveen Babbar; Eugene W Gerner; Robert A Casero
Journal:  Biochem J       Date:  2006-02-15       Impact factor: 3.857

3.  Pretreatment with anti-oxidants sensitizes oxidatively stressed human cancer cells to growth inhibitory effect of suberoylanilide hydroxamic acid (SAHA).

Authors:  Hirak S Basu; Amy Mahlum; Farideh Mehraein-Ghomi; Stacy J Kegel; Song Guo; Noel R Peters; George Wilding
Journal:  Cancer Chemother Pharmacol       Date:  2010-05-30       Impact factor: 3.333

4.  A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.

Authors:  Hirak S Basu; Todd A Thompson; Dawn R Church; Cynthia C Clower; Farideh Mehraein-Ghomi; Corey A Amlong; Christopher T Martin; Patrick M Woster; Mary J Lindstrom; George Wilding
Journal:  Cancer Res       Date:  2009-09-22       Impact factor: 12.701

5.  Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct.

Authors:  Tracy Murray-Stewart; Nancy B Applegren; Wendy Devereux; Amy Hacker; Renee Smith; Yanlin Wang; Robert A Casero
Journal:  Biochem J       Date:  2003-07-15       Impact factor: 3.857

6.  Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism.

Authors:  Catherine S Coleman; Bruce A Stanley; A Daniel Jones; Anthony E Pegg
Journal:  Biochem J       Date:  2004-11-15       Impact factor: 3.857

7.  Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells.

Authors:  L Xiao; R A Casero
Journal:  Biochem J       Date:  1996-01-15       Impact factor: 3.857

8.  Lack of evidence for the association of ornithine decarboxylase (+316 G>A), spermidine/spermine acetyl transferase (-1415 T>C) gene polymorphisms with calcium oxalate stone disease.

Authors:  Ajda Coker-Gürkan; Serdar Arisan; Elif Damla Arisan; Narçin Palavan Unsal
Journal:  Biomed Rep       Date:  2013-10-21

Review 9.  Salivary RNA signatures in oral cancer detection.

Authors:  Prashanth Panta; Venkat Raghavender Venna
Journal:  Anal Cell Pathol (Amst)       Date:  2014-12-10       Impact factor: 2.916
  9 in total

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