Literature DB >> 1417784

Bovine colostrum CMP-NeuAc:Gal beta(1-->4)GlcNAc-R alpha(2-->6)-sialyltransferase is involved in the synthesis of the terminal NeuAc alpha(2-->6)GalNAc beta(1-->4)GlcNAc sequence occurring on N-linked glycans of bovine milk glycoproteins.

M Nemansky1, D H Van den Eijnden.   

Abstract

Bovine colostrum CMP-NeuAc:Gal beta(-->4)GlcNAc-R alpha(2-->6)-sialyltransferase (alpha 6-sialyltransferase) appears to be capable of catalysing alpha 6-sialylation of the disaccharide GalNAc beta(1-->4)GlcNAc to yield the trisaccharide NeuAc alpha(2-->6)GalNAc beta(1-->4)GlcNAc. This provides an enzymic basis for the occurrence of this sialylated structure on the N-linked glycans of a number of bovine milk glycoproteins. Competition experiments using Gal beta(1-->4)GlcNAc and GalNAc beta(-->4)GlcNAc as acceptors indicate that both substrates are recognized by a single active site on the alpha 6-sialyltransferase. Extrapolation of these results suggests that the NeuAc alpha(2-->6)GalNAc beta(1-->4)GlcNAc structural element occurring on the N-linked glycans of several human glycoproteins are similarly synthesized by the action of a Gal beta(1-->4)GlcNAc-R alpha(2-->6)-sialyltransferase.

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Year:  1992        PMID： 1417784      PMCID： PMC1133160          DOI： 10.1042/bj2870311

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

1.  Characterization of a thyroid sulfotransferase responsible for the 3-O-sulfation of terminal beta-D-galactosyl residues in N-linked carbohydrate units.

Authors:  Y Kato; R G Spiro
Journal:  J Biol Chem       Date:  1989-02-25       Impact factor: 5.157

2.  Specificity in the enzymic transfer of sialic acid to the oligosaccharide branches of b1- and triantennary glycopeptides of alpha 1-acid glycoprotein.

Authors:  D H van den Eijnden; D H Joziasse; L Dorland; H van Halbeek; J F Vliegenthart; K Schmid
Journal:  Biochem Biophys Res Commun       Date:  1980-02-12       Impact factor: 3.575

3.  Specificity of ovine submaxillary-gland sialyltransferases. Application of high-pressure liquid chromatography in the identification of sialo-oligosaccharide products.

Authors:  M L Bergh; P L Koppen; D H Van den Eijnden
Journal:  Biochem J       Date:  1982-02-01       Impact factor: 3.857

4.  A novel sialylated N-acetylgalactosamine-containing oligosaccharide is the major complex-type structure present in Bowes melanoma tissue plasminogen activator.

Authors:  A L Chan; H R Morris; M Panico; A T Etienne; M E Rogers; P Gaffney; L Creighton-Kempsford; A Dell
Journal:  Glycobiology       Date:  1991-03       Impact factor: 4.313

5.  Enzymatic properties of beta-D-galactoside alpha2 leads to 6 sialytransferase from bovine colostrum.

Authors:  J C Paulson; J I Rearick; R L Hill
Journal:  J Biol Chem       Date:  1977-04-10       Impact factor: 5.157

6.  Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose.

Authors:  J C Paulson; W E Beranek; R L Hill
Journal:  J Biol Chem       Date:  1977-04-10       Impact factor: 5.157

7.  Carbohydrate structure of a thrombin-like serine protease from Agkistrodon rhodostoma. Structure elucidation of oligosaccharides by methylation analysis, liquid secondary-ion mass spectrometry and proton magnetic resonance.

Authors:  G Pfeiffer; U Dabrowski; J Dabrowski; S Stirm; K H Strube; R Geyer
Journal:  Eur J Biochem       Date:  1992-05-01

8.  Branch specificity of bovine colostrum CMP-sialic acid: N-acetyllactosaminide alpha 2----6-sialyltransferase. Interaction with biantennary oligosaccharides and glycopeptides of N-glycosylproteins.

Authors:  D H Joziasse; W E Schiphorst; D H van den Eijnden; J A van Kuik; H van Halbeek; J F Vliegenthart
Journal:  J Biol Chem       Date:  1985-01-25       Impact factor: 5.157

9.  Detection of beta-galactosyl(1 leads to 4)N-acetylglucosaminide alpha(2 leads to 3)-sialyltransferase activity in fetal calf liver and other tissues.

Authors:  D H Van den Eijnden; W E Schiphorst
Journal:  J Biol Chem       Date:  1981-04-10       Impact factor: 5.157

10.  Structure determination by 1H NMR spectroscopy of (sulfated) sialylated N-linked carbohydrate chains released from porcine thyroglobulin by peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase-F.

Authors:  P de Waard; A Koorevaar; J P Kamerling; J F Vliegenthart
Journal:  J Biol Chem       Date:  1991-03-05       Impact factor: 5.157
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  4 in total

Review 1.  Genetic engineering of recombinant glycoproteins and the glycosylation pathway in mammalian host cells.

Authors:  E Grabenhorst; P Schlenke; S Pohl; M Nimtz; H S Conradt
Journal:  Glycoconj J       Date:  1999-02       Impact factor: 2.916

2.  Alpha-lactalbumin affects the acceptor specificity of Lymnaea stagnalis albumen gland UDP-GalNAc:GlcNAc beta-R beta 1-->4-N-acetylgalactosaminyltransferase: synthesis of GalNAc beta 1-->4Glc.

Authors:  A P Neeleman; D H van de Eijnden
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

3.  Estrogen modulates expression of the glycosyltransferases that synthesize sulfated oligosaccharides on lutropin.

Authors:  S M Dharmesh; J U Baenziger
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

4.  Construction and characterization of stably transfected BHK-21 cells with human-type sialylation characteristic.

Authors:  P Schlenke; E Grabenhorst; M Nimtz; H S Conradt
Journal:  Cytotechnology       Date:  1999-07       Impact factor: 2.058
  4 in total

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