Literature DB >> 1416892

Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients.

L Naumovski1, J P Quinn, D Miyashiro, M Patel, K Bush, S B Singer, D Graves, T Palzkill, A M Arvin.   

Abstract

Ceftazidime is widely used in the therapy of infectious complications in neutropenic patients. We studied an outbreak of ceftazidime-resistant gram-negative bacillary infections in pediatric cancer patients receiving empirical ceftazidime therapy for neutropenic fever. Fourteen isolates (12 Klebsiella pneumoniae and 2 Escherichia coli) from 13 patients were studied. Specimens were obtained from multiple clinical sites including blood, urine, throat, and lung. The organisms were resistant to ceftazidime, aztreonam, and penicillins but remained susceptible to cephamycins and imipenem. All resistant isolates produced a novel beta-lactamase (TEM-26) with a pI of approximately 5.58, which was transferred by transformation to E. coli on a 7.9-kb nonconjugative plasmid which cotransferred resistance to trimethoprim-sulfamethoxazole. This enzyme readily hydrolyzed ceftazidime, aztreonam, and penicillins in a spectrophotometric assay. DNA sequencing data suggest that TEM-26 is derived from TEM-1.

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Year:  1992        PMID： 1416892      PMCID： PMC192997          DOI： 10.1128/AAC.36.9.1991

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Outbreak of nosocomial infections due to Klebsiella pneumoniae producing SHV-4 beta-lactamase.

Authors:  G Arlet; M J Sanson-le Pors; M Rouveau; G Fournier; O Marie; B Schlemmer; A Philippon
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1990-11       Impact factor: 3.267

2.  Molecular cloning and DNA homology of plasmid-mediated beta-lactamase genes.

Authors:  R C Levesque; A A Medeiros; G A Jacoby
Journal:  Mol Gen Genet       Date:  1987-02

3.  Novel beta-lactamase in a clinical isolate of Klebsiella pneumoniae conferring unusual resistance to beta-lactam antibiotics.

Authors:  R C Spencer; P F Wheat; T G Winstanley; D M Cox; S J Plested
Journal:  J Antimicrob Chemother       Date:  1987-12       Impact factor: 5.790

4.  The use of analytical isoelectric focusing for detection and identification of beta-lactamases.

Authors:  A Mathew; A M Harris; M J Marshall; G W Ross
Journal:  J Gen Microbiol       Date:  1975-05

5.  Characterization of the plasmid genes blaT-4 and blaT-5 which encode the broad-spectrum beta-lactamases TEM-4 and TEM-5 in enterobacteriaceae.

Authors:  W Sougakoff; A Petit; S Goussard; D Sirot; A Bure; P Courvalin
Journal:  Gene       Date:  1989-05-30       Impact factor: 3.688

6.  Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens.

Authors:  H Knothe; P Shah; V Krcmery; M Antal; S Mitsuhashi
Journal:  Infection       Date:  1983 Nov-Dec       Impact factor: 3.553

7.  Substitution of lysine at position 104 or 240 of TEM-1pTZ18R beta-lactamase enhances the effect of serine-164 substitution on hydrolysis or affinity for cephalosporins and the monobactam aztreonam.

Authors:  J A Sowek; S B Singer; S Ohringer; M F Malley; T J Dougherty; J Z Gougoutas; K Bush
Journal:  Biochemistry       Date:  1991-04-02       Impact factor: 3.162

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  Effect of fructose and other carbohydrates on the surface properties, lipoteichoic acid production, and extracellular proteins of Streptococcus mutans Ingbritt grown in continuous culture.

Authors:  L Hardy; N A Jacques; H Forester; L K Campbell; K W Knox; A J Wicken
Journal:  Infect Immun       Date:  1981-01       Impact factor: 3.441

10.  Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae.

Authors:  J P Quinn; D Miyashiro; D Sahm; R Flamm; K Bush
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191
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  58 in total

1.  Molecular epidemiology of a cluster of cases due to Klebsiella pneumoniae producing SHV-5 extended-spectrum beta-lactamase in the premature intensive care unit of a Hungarian hospital.

Authors:  D Szabó; Z Filetóth; J Szentandrássy; M Némedi; E Tóth; C Jeney; G Kispál; F Rozgonyi
Journal:  J Clin Microbiol       Date:  1999-12       Impact factor: 5.948

Review 2.  Plasmid-determined AmpC-type beta-lactamases.

Authors:  Alain Philippon; Guillaume Arlet; George A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

Review 3.  Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.

Authors:  P A Bradford
Journal:  Clin Microbiol Rev       Date:  2001-10       Impact factor: 26.132

4.  Emergence of community-acquired extended-spectrum beta-lactamase Escherichia coli (ESBLEC) in Honolulu: a case series of three individuals with community-acquired ESBLEC bacteriuria.

Authors:  Reid R Hoshide; Heath Chung; Jinichi Tokeshi
Journal:  Hawaii Med J       Date:  2011-09

5.  In memoriam: John P. Quinn, MD.

Authors:  Federico Perez; Cesar A Arias; Karen Bush; George L Drusano; Karen Lolans; L Silvia Munoz-Price; David P Nicolau; Anne Marie Queenan; Louis B Rice; John Segreti; David M Shlaes; Robert A Weinstein; Robert A Bonomo
Journal:  Clin Infect Dis       Date:  2013-12-12       Impact factor: 9.079

6.  Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strains causing nosocomial outbreaks of infection in the United Kingdom.

Authors:  K Shannon; P Stapleton; X Xiang; A Johnson; H Beattie; F El Bakri; B Cookson; G French
Journal:  J Clin Microbiol       Date:  1998-10       Impact factor: 5.948

7.  Multiply resistant Klebsiella pneumoniae strains from two Chicago hospitals: identification of the extended-spectrum TEM-12 and TEM-10 ceftazidime-hydrolyzing beta-lactamases in a single isolate.

Authors:  P A Bradford; C E Cherubin; V Idemyor; B A Rasmussen; K Bush
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

8.  beta-Lactamases responsible for resistance to expanded-spectrum cephalosporins in Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis isolates recovered in South Africa.

Authors:  J D Pitout; K S Thomson; N D Hanson; A F Ehrhardt; E S Moland; C C Sanders
Journal:  Antimicrob Agents Chemother       Date:  1998-06       Impact factor: 5.191

9.  Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates in a district hospital in Taiwan.

Authors:  P Y Liu; J C Tung; S C Ke; S L Chen
Journal:  J Clin Microbiol       Date:  1998-09       Impact factor: 5.948

10.  Can results obtained with commercially available MicroScan microdilution panels serve as an indicator of beta-lactamase production among escherichia coli and Klebsiella isolates with hidden resistance to expanded-spectrum cephalosporins and aztreonam?

Authors:  E S Moland; C C Sanders; K S Thomson
Journal:  J Clin Microbiol       Date:  1998-09       Impact factor: 5.948
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