| Literature DB >> 1415832 |
P F Renshaw1, A R Guimaraes, M Fava, J F Rosenbaum, J D Pearlman, J G Flood, P R Puopolo, K Clancy, R G Gonzalez.
Abstract
In vivo 19fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain:plasma ratio of the parent drug plus the metabolite was significantly elevated to 2.6 (SD = 1.0) (95% confidence interval = 1.9-3.3). This accumulation may have implications for understanding both the therapeutic and the toxic effects of fluoxetine.Entities:
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Year: 1992 PMID： 1415832 DOI： 10.1176/ajp.149.11.1592
Source DB: PubMed Journal: Am J Psychiatry ISSN： 0002-953X Impact factor: 18.112