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Literature DB >> 14127605

AN ESTIMATE OF REFLECTION COEFFICIENTS FOR RABBIT HEART CAPILLARIES.

Abstract

Isolated perfused rabbit hearts have been used to determine the reflection coefficients, sigma, of the heart capillaries to certain lipoid-insoluble substances. This was done by initially perfusing the heart with a Ringer solution containing no test molecule and then suddenly switching to a solution which differed from the original only by containing a small amount of test substance. This produced a loss of weight of the heart which was continuously recorded as a function of time. Taking the "zero" time rate of weight change and using an equation given by Kedem and Katchalsky reflection coefficients for urea, sucrose, raffinose, and inulin were obtained. These turned out to be 0.1, 0.3, 0.38, and 0.69 respectively. Using the approach of Durbin and Solomon equivalent pore radii were estimated to be about 35 Angstroms.

Entities: Chemical Species

Keywords: CAPILLARY PERMEABILITY; CORONARY VESSELS; EXPERIMENTAL LAB STUDY; HEART; PERFUSION; RABBITS

Mesh：

Substances：
Sucrose
Inulin

Year: 1964 PMID： 14127605 PMCID： PMC2195348 DOI： 10.1085/jgp.47.4.667

Source DB: PubMed Journal: J Gen Physiol ISSN： 0022-1295 Impact factor: 4.086

12 in total

Review 10. Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors.

Authors: Hemant Sarin
Journal: J Transl Med Date: 2009-09-01 Impact factor: 5.531

AN ESTIMATE OF REFLECTION COEFFICIENTS FOR RABBIT HEART CAPILLARIES.

1. Blood capillaries of the heart and other organs.

2. Thermodynamic analysis of the permeability of biological membranes to non-electrolytes.

3. Filtration, diffusion, and molecular sieving through porous cellulose membranes.

4. Relation between pressure and concentration difference across membranes permeable to solute and solvent.

5. Passage of molecules through capillary wals.

6. Kinetics concerned with distribution of isotopic water in isolated perfused dog heart and skeletal muscle.

7. Transport through biological membranes.

8. Determination of the effective hydrodynamic radii of small molecules by viscometry.

9. Water flow through frog gastric mucosa.

10. Osmotic flow of water across permeable cellulose membranes.

1. An integrative model of coupled water and solute exchange in the heart.

2. Transient transcapillary exchange of water driven by osmotic forces in the heart.

3. Permeability of barnacle muscle fibers to water and nonelectrolytes.

4. GENTEX, a general multiscale model for in vivo tissue exchanges and intraorgan metabolism.

Review 5. Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function.

6. Filtration coefficient and osmotic reflection coefficient to albumin in rabbit submandibular gland capillaries.

7. Heart capillary permeability to lipid-insoluble molecules.

8. Lack of selectivity to small ions in paracellular pathways in cerebral and muscle capillaries of the frog.

9. A reassessment of mercury in silastic strain gauge plethysmography for microvascular permeability assessment in man.

Review 10. Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors.