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Literature DB >> 14126052

A SENSITIVE METHOD FOR THE ASSAY OF CATECHOL AMINES.

Abstract

A strip of fundus from a rat's stomach was suspended in Krebs solution containing 5-hydroxytryptamine. Movements of the muscle were recorded by means of a frontal writing lever giving a magnification of sixteen-times. The strip relaxed when isoprenaline, adrenaline or noradrenaline was added to the organ-bath in concentrations of 0.2 to 2 ng/ml. The preparation was most sensitive to isoprenaline and least sensitive to noradrenaline. The components of a mixture of two catechol amines could be assayed by superfusing the rat stomach and a chick rectum in the same stream of fluid.

Entities: Chemical Species

Keywords: BIOLOGICAL ASSAY; EPINEPHRINE; EXPERIMENTAL LAB STUDY; ISOPROTERENOL; NOREPINEPHRINE; PHARMACOLOGY; POULTRY; RATS; RECTUM; STOMACH

Mesh：

Substances：

Year: 1964 PMID： 14126052 PMCID： PMC1703914 DOI： 10.1111/j.1476-5381.1964.tb01560.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

8 in total

20 in total

A SENSITIVE METHOD FOR THE ASSAY OF CATECHOL AMINES.

1. The output of sympathetic amines from the cat's adrenal gland in response to splanchnic nerve activity.

2. The concentration of adrenaline in the plasma of rabbits treated with reserpine.

3. The relation between the tension and the high-energy phosphate content of smooth muscle.

4. The technique of superfusion.

5. The estimation of adrenaline and allied substances in blood.

6. The assay of substances from the adrenal medulla.

7. The nature of hepatic and splenic sympathin.

8. A sensitive method for the assay of 5-hydroxytryptamine.

1. The formation of synapses in reinnervated and cross-reinnervated striated muscle during development.

2. Investigation into the mode of action of histamine on the isolated rabbit heart.

3. Effects of tetrodotoxin on innervated smooth muscle preparations.

Review 4. The release and fate of vaso-active hormones in the circulation.

5. The release of catechol amines from the adrenal medulla by histamine.

6. The release of catecholamines from the adrenal medulla by peptides.

7. The assay of catecholamines released into the circulation of the guinea-pig by angiotensin.

8. The effects of alteration of blood-volume on the concentration of circulating angiotensin in anaesthetized dogs.

9. Angiotensin II-like activity in circulating arterial blood in immature and adult rabbits.

10. The continuous estimation of angiotensin formed in the circulation of the dog.