| Literature DB >> 1411511 |
E Henderson1, P G Haydon, D S Sakaguchi.
Abstract
Observation of filamentous actin (F-actin) in living cells is currently limited to the resolution of the light microscope. Higher resolution procedures require sample fixation and preclude dynamic studies. The atomic force microscope (AFM) can image and manipulate samples at very high, sometimes atomic resolution by scanning a fine tip over the surface of interest and detecting physical interactions between the tip and sample. This study demonstrates that F-actin can be readily resolved in living cells with the AFM and that the dynamic properties of F-actin are easily observed.Entities:
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Year: 1992 PMID： 1411511 DOI： 10.1126/science.1411511
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728