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Literature DB >> 14113110

SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY.

Abstract

Hybrid, bivalent antibody molecules bearing specific combining sites for both ovalbumin and bovine gamma globulin were produced by reoxidation of a mixture of the 3.5S fragments of the two specifically purified antibodies. The dual specificity and the properties of the hybrid antibody were demonstrated by mixed agglutination and two stage agglutination experiments, and by test systems utilizing inhibition of agglutination or dispersal of agglutinates followed by antiglobulin reactions.

Entities: Gene Species

Keywords: AGGLUTINATION; ANTIBODIES; CATTLE; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN; HEMAGGLUTINATION; MERCAPTOETHYLAMINES; OVALBUMIN; PEPSIN; RABBITS

Mesh：

Substances：

Year: 1964 PMID： 14113110 PMCID： PMC2137801 DOI： 10.1084/jem.119.1.151

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

17 in total

1. Preparation and properties of antibodies to sheep ervthrocvtes.

Authors: K AMIRAIAN; E J LEIKHIM
Journal: J Immunol Date: 1961-09 Impact factor: 5.422

2. Separation of univalent fragments of rabbit antibody by reduction of a single, labile disulphide bond.

Authors: A NISONOFF; G MARKUS; F C WISSLER
Journal: Nature Date: 1961-01-28 Impact factor: 49.962

3. Recombination of a mixture of univalent antibody fragments of different specificity.

Authors: A NISONOFF; M M RIVERS
Journal: Arch Biochem Biophys Date: 1961-05 Impact factor: 4.013

4. Properties of the major component of a peptic digest of rabbit antibody.

Authors: A NISONOFF; F C WISSLER; L N LIPMAN
Journal: Science Date: 1960-12-09 Impact factor: 47.728

5. The similar specificity of the combining sites of an individual antibody molecule.

Authors: A NISONOFF; M H WINKLER; D PRESSMAN
Journal: J Immunol Date: 1959-03 Impact factor: 5.422

6. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.

Authors: R R PORTER
Journal: Biochem J Date: 1959-09 Impact factor: 3.857

7. Studies of hypersensitivity to low molecular weight substances. III. The 2,4-dinitrophenyl group as a determinant in the preciptin reaction.

Authors: H N EISEN; M E CARSTEN; S BELMAN
Journal: J Immunol Date: 1954-11 Impact factor: 5.422

8. SEROLOGIC STUDIES OF PROTEOLYTIC FRAGMENTS OF RABBIT AGGLUTINATING ANTIBODIES.

Authors: H Fudenberg; W J Mandy; A Nisonoff
Journal: J Clin Invest Date: 1962-12 Impact factor: 14.808

9. Linked anti-A and anti-B antibodies from group O sera.

Authors: B E DODD
Journal: Br J Exp Pathol Date: 1952-02

10. Studies on the rheumatoid and related serum factors. II. Relation of anti-human and anti-rabbit gamma globulin factors in rheumatoid arthritis serums.

Authors: F MILGROM; E WITEBSKY; R GOLDSTEIN; U LOZA
Journal: JAMA Date: 1962-08-11 Impact factor: 56.272

12 in total

1. A STUDY OF THE EFFECTS OF SALT AND OF PH ON PRECIPITATION OF ANTIGEN--ANTIBODY COMPOUNDS.

Authors: A KLECZKOWSKI
Journal: Immunology Date: 1965-02 Impact factor: 7.397

2. Quantitation of antibody to non-hemagglutinating viruses by single radial hemolysis: serological test for human coronaviruses.

Authors: J C Hierholzer; G A Tannock
Journal: J Clin Microbiol Date: 1977-06 Impact factor: 5.948

SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY.

1. Preparation and properties of antibodies to sheep ervthrocvtes.

2. Separation of univalent fragments of rabbit antibody by reduction of a single, labile disulphide bond.

3. Recombination of a mixture of univalent antibody fragments of different specificity.

4. Properties of the major component of a peptic digest of rabbit antibody.

5. The similar specificity of the combining sites of an individual antibody molecule.

6. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.

7. Studies of hypersensitivity to low molecular weight substances. III. The 2,4-dinitrophenyl group as a determinant in the preciptin reaction.

8. SEROLOGIC STUDIES OF PROTEOLYTIC FRAGMENTS OF RABBIT AGGLUTINATING ANTIBODIES.

9. Linked anti-A and anti-B antibodies from group O sera.

10. Studies on the rheumatoid and related serum factors. II. Relation of anti-human and anti-rabbit gamma globulin factors in rheumatoid arthritis serums.

1. A STUDY OF THE EFFECTS OF SALT AND OF PH ON PRECIPITATION OF ANTIGEN--ANTIBODY COMPOUNDS.

2. Quantitation of antibody to non-hemagglutinating viruses by single radial hemolysis: serological test for human coronaviruses.

Review 3. Symmetry breaking: bispecific antibodies, the beginnings, and 50 years on.

Review 4. Some recent developments in immunocytochemistry.

5. Monoclonal IgG1 immunoglobulinaemia with strictly pH dependent cryoprecipitability.

6. Antisperm antibody titres, immune complex deposition and immunocompetence in long-term vasectomized mice.

7. Experimental mycosis in immunosuppressed rabbits. I. Acute and chronic candidosis.

8. CDR loop interactions can determine heavy and light chain pairing preferences in bispecific antibodies.

Review 9. Development of Bispecific Antibody for Cancer Immunotherapy: Focus on T Cell Engaging Antibody.

Review 10. Translation and Clinical Development of Bispecific T-cell Engaging Antibodies for Cancer Treatment.