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Literature DB >> 22896757

Symmetry breaking: bispecific antibodies, the beginnings, and 50 years on.

Gert Riethmüller¹.

Abstract

Keywords: bispecific antibodies; bispecific single-chain antibody; blinatumomab; catumaxomab

Mesh：

Substances：
Antibodies, Bispecific

Year: 2012 PMID： 22896757 PMCID： PMC3380354

Source DB: PubMed Journal: Cancer Immun ISSN： 1424-9634

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51 in total

1. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.

Authors: Rachael D Aubert; Alice O Kamphorst; Surojit Sarkar; Vaiva Vezys; Sang-Jun Ha; Daniel L Barber; Lilin Ye; Arlene H Sharpe; Gordon J Freeman; Rafi Ahmed
Journal: Proc Natl Acad Sci U S A Date: 2011-12-12 Impact factor: 11.205

2. Separation and isolation of fractions of rabbit gamma-globulin containing the antibody and antigenic combining sites.

Authors: R R PORTER
Journal: Nature Date: 1958-09-06 Impact factor: 49.962

3. Recombination of a mixture of univalent antibody fragments of different specificity.

Authors: A NISONOFF; M M RIVERS
Journal: Arch Biochem Biophys Date: 1961-05 Impact factor: 4.013

Review 4. Strategies and challenges for the next generation of therapeutic antibodies.

Authors: Alain Beck; Thierry Wurch; Christian Bailly; Nathalie Corvaia
Journal: Nat Rev Immunol Date: 2010-05 Impact factor: 53.106

5. 'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization.

Authors: J B Ridgway; L G Presta; P Carter
Journal: Protein Eng Date: 1996-07

6. T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3- bispecific single-chain antibody construct.

Authors: Torsten Dreier; Patrick A Baeuerle; Iduna Fichtner; Michael Grün; Bernd Schlereth; Grit Lorenczewski; Peter Kufer; Ralf Lutterbüse; Gert Riethmüller; Per Gjorstrup; Ralf C Bargou
Journal: J Immunol Date: 2003-04-15 Impact factor: 5.422

7. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.

Authors: Max S Topp; Peter Kufer; Nicola Gökbuget; Mariele Goebeler; Matthias Klinger; Svenja Neumann; Heinz-A Horst; Thorsten Raff; Andreas Viardot; Mathias Schmid; Matthias Stelljes; Markus Schaich; Evelyn Degenhard; Rudolf Köhne-Volland; Monika Brüggemann; Oliver Ottmann; Heike Pfeifer; Thomas Burmeister; Dirk Nagorsen; Margit Schmidt; Ralf Lutterbuese; Carsten Reinhardt; Patrick A Baeuerle; Michael Kneba; Hermann Einsele; Gert Riethmüller; Dieter Hoelzer; Gerhard Zugmaier; Ralf C Bargou
Journal: J Clin Oncol Date: 2011-05-16 Impact factor: 44.544

8. Hybrid antibody-mediated lysis of virus-infected cells.

Authors: U D Staerz; J W Yewdell; M J Bevan
Journal: Eur J Immunol Date: 1987-04 Impact factor: 5.532

9. Induction of cytotoxicity in resting human T lymphocytes bound to tumor cells by antibody heteroconjugates.

Authors: G Jung; J A Ledbetter; H J Müller-Eberhard
Journal: Proc Natl Acad Sci U S A Date: 1987-07 Impact factor: 11.205

10. CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans.

Authors: Rong Rong Huang; Jason Jalil; James S Economou; Bartosz Chmielowski; Richard C Koya; Stephen Mok; Hooman Sazegar; Elizabeth Seja; Arturo Villanueva; Jesus Gomez-Navarro; John A Glaspy; Alistair J Cochran; Antoni Ribas
Journal: Clin Cancer Res Date: 2011-05-10 Impact factor: 12.531

30 in total

1. Stability engineering of anti-EGFR scFv antibodies by rational design of a lambda-to-kappa swap of the VL framework using a structure-guided approach.

Authors: Andreas Lehmann; Josephine H F Wixted; Maxim V Shapovalov; Heinrich Roder; Roland L Dunbrack; Matthew K Robinson
Journal: MAbs Date: 2015-09-04 Impact factor: 5.857

2. Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry.

Authors: Wolfgang Schaefer; Hans R Völger; Stefan Lorenz; Sabine Imhof-Jung; Jörg T Regula; Christian Klein; Michael Mølhøj
Journal: MAbs Date: 2015-10-23 Impact factor: 5.857

3. Bispecific small molecule-antibody conjugate targeting prostate cancer.

Authors: Chan Hyuk Kim; Jun Y Axup; Brian R Lawson; Hwayoung Yun; Virginie Tardif; Sei Hyun Choi; Quan Zhou; Anna Dubrovska; Sandra L Biroc; Robin Marsden; Jason Pinstaff; Vaughn V Smider; Peter G Schultz
Journal: Proc Natl Acad Sci U S A Date: 2013-10-14 Impact factor: 11.205

4. Expression of inhibitory receptors on intratumoral T cells modulates the activity of a T cell-bispecific antibody targeting folate receptor.

Authors: Jens Schreiner; Daniela S Thommen; Petra Herzig; Marina Bacac; Christian Klein; Andreas Roller; Anton Belousov; Victor Levitsky; Spasenija Savic; Wolfgang Moersig; Franziska Uhlenbrock; Viola A Heinzelmann-Schwarz; Pablo Umana; Pavel Pisa; M von Bergwelt-Baildon; Didier Lardinois; Philipp Müller; Vaios Karanikas; Alfred Zippelius
Journal: Oncoimmunology Date: 2015-06-24 Impact factor: 8.110

5. Engager T cells: a new class of antigen-specific T cells that redirect bystander T cells.

Authors: Kota Iwahori; Sunitha Kakarla; Mireya P Velasquez; Feng Yu; Zongzhen Yi; Claudia Gerken; Xiao-Tong Song; Stephen Gottschalk
Journal: Mol Ther Date: 2014-08-21 Impact factor: 11.454

Review 6. [Biologics].

Authors: J R Kalden
Journal: Z Rheumatol Date: 2016-08 Impact factor: 1.372