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Literature DB >> 14110744

QUANTITATIVE EVALUATION OF GUINEA-PIG ANAPHYLAXIS IN VIVO.

Abstract

Two methods for recording bronchoconstrictor responses to antigen injected into sensitized guinea-pigs have been used to show that the dose/response relationship is a normal pharmacological one characterized by a sigmoid curve. Studies of desensitization indicate that the progressive decrease in sensitivity to repeated administrations of the same dose of antigen follows an exponential pattern. It is suggested that this approach might form a basis for reliable quantitative investigations of anaphylactic phenomena.

Entities: Species

Keywords: ANAPHYLAXIS; ANTIGENS; BRONCHI; EXPERIMENTAL LAB STUDY; GUINEA PIGS; PHARMACOLOGY

Mesh：

Substances：

Year: 1963 PMID： 14110744 PMCID： PMC1703890 DOI： 10.1111/j.1476-5381.1963.tb02012.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

11 in total

1. [Studies on the part played by histamine in anaphylactic asthma and observations on the induction and behavior of asthmatic and circulatory symptoms of anaphylactic shock fragments in guinea pigs].

Authors: J ALBERTY
Journal: Int Arch Allergy Appl Immunol Date: 1959

2. The bronchoconstrictor action of bradykinin in the guinea-pig.

Authors: H O COLLIER; J A HOLGATE; M SCHACHTER; P G SHORLEY
Journal: Br J Pharmacol Chemother Date: 1960-06

3. Comparative effects of compound 48/80, histamine and antigen, and the relation between challenging dose of antigen and anaphylactic response in guinea pigs sensitized to egg albumin.

Authors: E A CARR; C F CURRY
Journal: Int Arch Allergy Appl Immunol Date: 1956

4. Experimental design for bioassay of a material inducing strong tachyphylactic effect (anaphylatoxin).

Authors: E M ROCHA SILVA; A M ROTHSCHILD
Journal: Br J Pharmacol Chemother Date: 1956-09

5. Drug allergy.

Authors: E A CARR
Journal: Pharmacol Rev Date: 1954-12 Impact factor: 25.468

6. Contributions to the physiology of the lungs: Part I. The bronchial muscles, their innervation, and the action of drugs upon them.

Authors: W E Dixon
Journal: J Physiol Date: 1903-03-16 Impact factor: 5.182

3. The evaluation of anaphylactic bronchoconstrictor effects induced by intravenous and aerosol challenge in the anaesthetized guinea-pig.

Authors: I Carney
Journal: Br J Pharmacol Date: 1969-10 Impact factor: 8.739

3 in total

QUANTITATIVE EVALUATION OF GUINEA-PIG ANAPHYLAXIS IN VIVO.

1. [Studies on the part played by histamine in anaphylactic asthma and observations on the induction and behavior of asthmatic and circulatory symptoms of anaphylactic shock fragments in guinea pigs].

2. The bronchoconstrictor action of bradykinin in the guinea-pig.

3. Comparative effects of compound 48/80, histamine and antigen, and the relation between challenging dose of antigen and anaphylactic response in guinea pigs sensitized to egg albumin.

4. Experimental design for bioassay of a material inducing strong tachyphylactic effect (anaphylatoxin).

5. Drug allergy.

6. Contributions to the physiology of the lungs: Part I. The bronchial muscles, their innervation, and the action of drugs upon them.

7. The influence of duration of sensitization of anaphylaxis in the guinea-pig.

8. The effect of cortisone upon some experimental hypersensitivity reactions.

9. Repeatable micro-shocks of constant strength in guinea-pig anaphylaxis.

10. Influence of ACTH on anaphylactic shock in guinea pigs.

1. A quantitative study of repeated anaphylactic reactions in isolated tissues.

2. The nature of adrenergic mechanisms involved in anaphylatoxin activity in the guinea-pig.

3. The evaluation of anaphylactic bronchoconstrictor effects induced by intravenous and aerosol challenge in the anaesthetized guinea-pig.