Literature DB >> 13811230

The bronchoconstrictor action of bradykinin in the guinea-pig.

H O COLLIER, J A HOLGATE, M SCHACHTER, P G SHORLEY.   

Abstract

Bradykinin was found to be a potent bronchoconstrictor agent in the guinea-pig anaesthetized with urethane. This action was not affected by vagotomy, or by treatment of the animal with mepyramine, atropine, lysergic acid diethylamide, or cortisone. Adrenaline and isoprenaline suppressed the bronchoconstrictor responses to bradykinin and histamine. Small doses of acetylsalicylic acid, however, suppressed only that to bradykinin. Bradykinin also produced bronchoconstriction in the isolated perfused lungs of the guinea-pig. The closely related peptide, wasp kinin, was also a potent bronchoconstrictor.

Entities:  

Keywords:  BRONCHI/pharmacology; KALLIKREIN/pharmacology

Mesh：

Substances：

Year:  1960        PMID： 13811230      PMCID： PMC1481942          DOI： 10.1111/j.1476-5381.1960.tb01247.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  2 in total

1.  A comparative study of kinin, kallidin, and bradykinin.

Authors:  D J HOLDSTOCK; A P MATHIAS; M SCHACHTER
Journal:  Br J Pharmacol Chemother       Date:  1957-06

2.  The effects of 5-hydroxytryptamine and its antagonists on tidal air.

Authors:  H KONZETT
Journal:  Br J Pharmacol Chemother       Date:  1956-09
  2 in total
  41 in total

1.  [ON THE STIMULATION OF RESPIRATION BY BRADYKININ AND KALLIDIN].

Authors:  V GJURIS; B HEICKE; E WESTERMANN
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1964-07-28

2.  [Recent results in the field of plasma kinins].

Authors:  I TRAUTSCHOLD; G RUDEL
Journal:  Klin Wochenschr       Date:  1963-04-01

3.  Actions of some peptides on bronchial muscle.

Authors:  K D BHOOLA; H O COLLIER; M SCHACHTER; P G SHORLEY
Journal:  Br J Pharmacol Chemother       Date:  1962-08

4.  The effect of bradykinin in an isolated perfused dog lung preparation.

Authors:  B A WAALER
Journal:  J Physiol       Date:  1961-08       Impact factor: 5.182

5.  Pharmacological actions of eledoisin on extravascular smooth muscle.

Authors:  V Erspamer; G F Erspamer
Journal:  Br J Pharmacol Chemother       Date:  1962-10

6.  Effect of some drugs on human umbilical artery in vitro.

Authors:  S D Gokhale; O D Gulati; L V Kelkar; V V Kelkar
Journal:  Br J Pharmacol Chemother       Date:  1966-08

7.  Effects of intravenous administration of slow-reacting substance of anaphylaxis, histamine, bradykinin, and prostaglandin F2alpha on pulmonary mechanics in the guinea pig.

Authors:  J M Drazen; K F Austen
Journal:  J Clin Invest       Date:  1974-06       Impact factor: 14.808

8.  Effect of beta-adrenoceptive blocking agents on the response to bronchoconstrictor drugs in the guinea-pig air overflow preparation. Appendix describing a new modification of the air overflow method.

Authors:  D T Burden; M W Parkes; D G Gardiner
Journal:  Br J Pharmacol       Date:  1971-01       Impact factor: 8.739

9.  Responses of skin blood vessels to bradykinin, histamine and 5-hydroxytryptamine.

Authors:  M Greaves; S Shuster
Journal:  J Physiol       Date:  1967-11       Impact factor: 5.182

10.  Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs.

Authors:  T Sakamoto; H Tsukagoshi; P J Barnes; K F Chung
Journal:  Agents Actions       Date:  1993-07
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