Literature DB >> 14110743

ANTI-EMETIC ACTIVITY OF PHENOTHIAZINES IN RELATION TO THEIR CHEMICAL STRUCTURE.

K P BHARGAVA, O CHANDRA.   

Abstract

Twelve phenothiazine derivatives have been studied for anti-emetic potency in dogs against emesis induced by apomorphine. The PD(50)s of all the compounds were determined and the activities compared with chlorpromazine hydrochloride as standard. Thioproperazine methanesulphonate was 300 times more active than chlorpromazine hydrochloride and twice as active as perphenazine sodium citrate. The anti-emetic activity of the compounds has been correlated with their chemical structure.

Entities:  

Keywords:  ANTIEMETICS; APOMORPHINE; CHEMISTRY, PHARMACEUTICAL; CHLORPROMAZINE; DOGS; EXPERIMENTAL LAB STUDY; PERPHENAZINE; PHARMACOLOGY; PHENOTHIAZINES; PROCHLORPERAZINE; THIOPROPERAZINE; THIORIDAZINE; TRANQUILIZING AGENTS; TRIFLUOPERAZINE

Mesh：

Substances：

Year:  1963        PMID： 14110743      PMCID： PMC1703878          DOI： 10.1111/j.1476-5381.1963.tb02011.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  5 in total

1.  Antiemetic action of fluphenazine (Prolixin): a comparison with other phenothiazines.

Authors:  R J LAFFAN; D P PAPANDRIANOS; J C BURKE; B N CR AVER
Journal:  J Pharmacol Exp Ther       Date:  1961-01       Impact factor: 4.030

2.  A comparison of some phenothiazine derivatives in inhibiting apomorphine-induced emesis.

Authors:  H ROSENKILDE; W M GOVIER
Journal:  J Pharmacol Exp Ther       Date:  1957-07       Impact factor: 4.030

3.  Perphenazine, a potent and effective antiemetic.

Authors:  S C WANG
Journal:  J Pharmacol Exp Ther       Date:  1958-08       Impact factor: 4.030

4.  The anti-emetic activity of 10-(gamma-dimethylaminopropyl)-2-chlorophenothiazine (chlorpromazine) in dog and cat.

Authors:  E D BRAND; T D HARRIS; H L BORISON; L S GOODMAN
Journal:  J Pharmacol Exp Ther       Date:  1954-01       Impact factor: 4.030

5.  [Pharmacodynamic properties of 3-chloro-10-(3-dimethylaminopropyl)-phenothiazine hydrochloride (R.P. 4560); experimental study of a new substance used in potentialized anesthesia and in artificial hibernation].

Authors:  S COURVOISIER; J FOURNEL; R DUCROT; M KOLSKY; P KOETSCHET
Journal:  Arch Int Pharmacodyn Ther       Date:  1953-01
  5 in total
  5 in total

Review 1.  Specific effects of reactive thiol drugs on mitochondrial bioenergetics.

Authors:  Iseli L Nantes; Tiago Rodrigues; Antonio C F Caires; Rodrigo L O R Cunha; Felipe S Pessoto; César H Yokomizo; Juliana C Araujo-Chaves; Priscila A Faria; Debora P Santana; Carolina G dos Santos
Journal:  J Bioenerg Biomembr       Date:  2011-02       Impact factor: 2.945

2.  Translating Drugs From Animals to Humans: Do We Need to Prove Efficacy?

Authors:  Gary D Novack
Journal:  Transl Vis Sci Technol       Date:  2013-09-12       Impact factor: 3.283

3.  Acepromazine and Chlorpromazine as Pharmaceutical-grade Alternatives to Chlorprothixene for Pupillary Light Reflex Imaging in Mice.

Authors:  Samantha S Eckley; Jason S Villano; Nora S Kuo; Kwoon Y Wong
Journal:  J Am Assoc Lab Anim Sci       Date:  2020-01-08       Impact factor: 1.232

4.  Anti-apomorphine effects of phenothiazine drug metabolites.

Authors:  E Morel; K G Lloyd; S G Dahl
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

5.  TRANQUILLIZING AND HYPOTENSIVE ACTIVITIES OF TWELVE PHENOTHIAZINES.

Authors:  K P BHARGAVA; O M CHANDRA
Journal:  Br J Pharmacol Chemother       Date:  1964-02
  5 in total

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