Literature DB >> 14107464

PARATHION ACTIVATION BY LIVERS OF AQUATIC AND TERRESTRIAL VERTEBRATES.

J L POTTER, R D O'BRIEN.   

Abstract

Liver slices from seven terrestrial and six aquatic animals studied "activated" parathion, converting it to paraoxon, a potent anticholinesterase. Although there are similarities between the liver systems which activate parathion and which degrade drugs such as aminopyrine and phenacetin, liver slices of aquatic vertebrates can activate parathion but cannot degrade such drugs.

Entities:  

Keywords:  BIRDS; CHOLINESTERASE; ENZYME INHIBITORS; EXPERIMENTAL LAB STUDY; FISHES; FROGS; GUINEA PIGS; LIVER FUNCTION; METABOLISM; MICE; PARATHION; PHARMACOLOGY; RABBITS; RATS; REPTILES; SWINE; TOADS

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Substances：

Year:  1964        PMID： 14107464     DOI： 10.1126/science.144.3614.55

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Accumulation, metabolism and toxicity of parathion in tadpoles.

Authors:  R J Hall
Journal:  Bull Environ Contam Toxicol       Date:  1990-04       Impact factor: 2.151

Review 2.  Comparative metabolism and selectivity of organophosphate and carbamate insecticides.

Authors:  R M Hollingworth
Journal:  Bull World Health Organ       Date:  1971       Impact factor: 9.408

3.  Metabolism of diazinon by fish liver microsomes.

Authors:  J W Hogan; C O Knowles
Journal:  Bull Environ Contam Toxicol       Date:  1972-07       Impact factor: 2.151

4.  Comparison of the metabolism of parathion by lobsters and rats.

Authors:  G P Carlson
Journal:  Bull Environ Contam Toxicol       Date:  1973-05       Impact factor: 2.151

5.  Effect of sesamex on brain acetylcholinesterase inhibition by parathion in fishes.

Authors:  J R Gibson; J L Ludke
Journal:  Bull Environ Contam Toxicol       Date:  1971 Mar-Apr       Impact factor: 2.151

6.  Studies on the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) in vitro.

Authors:  R A Neal
Journal:  Biochem J       Date:  1967-04       Impact factor: 3.857

7.  Trout hepatic enzyme activation of aflatoxin B1 in a mutagen assay system and the inhibitory effect of PCBs1.

Authors:  W T Stott; R O Sinnhuber
Journal:  Bull Environ Contam Toxicol       Date:  1978-01       Impact factor: 2.151

8.  Phthalate ester residues--their metabolism and analysis in fish.

Authors:  D L Stalling; J W Hogan; J L Johnson
Journal:  Environ Health Perspect       Date:  1973-01       Impact factor: 9.031

Review 9.  Relationship between biotransformation and the toxicity and fate of xenobiotic chemicals in fish.

Authors:  J J Lech; J R Bend
Journal:  Environ Health Perspect       Date:  1980-02       Impact factor: 9.031
  9 in total

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