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Literature DB >> 1409703

Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases.

R T Premont¹, J Chen, H W Ma, M Ponnapalli, R Iyengar.

Abstract

cDNA encoding a hormone- and guanine nucleotide-stimulated adenylyl cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] (type 6) from rat liver and kidney has been cloned and expressed. This enzyme is stimulated by forskolin, guanosine 5'-[gamma-thio]triphosphate, and isoproterenol plus GTP but is not stimulated by beta gamma subunits of guanine nucleotide-binding proteins. A second form (type 5), which is 75% similar to type 6, has also been cloned. Both types 5 and 6 cDNAs have multiple messages. PCR-based detection of the mRNA for the type 5 and 6 enzymes indicates that both are widely distributed. Homology analyses indicate at least four distinct subfamilies of guanine nucleotide stimulatory protein-regulated adenylyl cyclases. Types 5 and 6 enzymes define one distinct subfamily of mammalian adenylyl cyclases. Diversity of one guanine nucleotide-binding protein-regulated effector may allow different modes of regulation of cell-surface signal transmission.

Entities: Chemical Gene Species

Mesh：

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Year: 1992 PMID： 1409703 PMCID： PMC50222 DOI： 10.1073/pnas.89.20.9809

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

26 in total

1. Isolation and characterization of a novel cardiac adenylylcyclase cDNA.

Authors: Y Ishikawa; S Katsushika; L Chen; N J Halnon; J Kawabe; C J Homcy
Journal: J Biol Chem Date: 1992-07-05 Impact factor: 5.157

2. Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain.

Authors: P G Feinstein; K A Schrader; H A Bakalyar; W J Tang; J Krupinski; A G Gilman; R R Reed
Journal: Proc Natl Acad Sci U S A Date: 1991-11-15 Impact factor: 11.205

3. A PCR procedure to determine the sequence of large polypeptides by rapid walking through a cDNA library.

Authors: I R Gibbons; D J Asai; N S Ching; G J Dolecki; G Mocz; C A Phillipson; H Ren; W J Tang; B H Gibbons
Journal: Proc Natl Acad Sci U S A Date: 1991-10-01 Impact factor: 11.205

Review 4. Guanylyl cyclases, a growing family of signal-transducing enzymes.

Authors: D Koesling; E Böhme; G Schultz
Journal: FASEB J Date: 1991-10 Impact factor: 5.191

5. Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain.

Authors: J Parma; D Stengel; M H Gannage; M Poyard; R Barouki; J Hanoune
Journal: Biochem Biophys Res Commun Date: 1991-08-30 Impact factor: 3.575

6. The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes.

Authors: T Katada; G M Bokoch; M D Smigel; M Ui; A G Gilman
Journal: J Biol Chem Date: 1984-03-25 Impact factor: 5.157

7. Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells.

Authors: M Yoshimura; D M Cooper
Journal: Proc Natl Acad Sci U S A Date: 1992-08-01 Impact factor: 11.205

8. Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation.

Authors: Y H Wong; A Federman; A M Pace; I Zachary; T Evans; J Pouysségur; H R Bourne
Journal: Nature Date: 1991-05-02 Impact factor: 49.962

9. Two forms of the bovine brain Go that stimulate the inositol trisphosphate-mediated Cl- currents in Xenopus oocytes. Distinct guanine nucleotide binding properties.

Authors: E Padrell; D J Carty; T M Moriarty; J D Hildebrandt; E M Landau; R Iyengar
Journal: J Biol Chem Date: 1991-05-25 Impact factor: 5.157

10. Odorant signal termination by olfactory UDP glucuronosyl transferase.

Authors: D Lazard; K Zupko; Y Poria; P Nef; J Lazarovits; S Horn; M Khen; D Lancet
Journal: Nature Date: 1991-02-28 Impact factor: 49.962

27 in total

1. Regions on adenylyl cyclase that are necessary for inhibition of activity by beta gamma and G(ialpha) subunits of heterotrimeric G proteins.

Authors: C Wittpoth; K Scholich; Y Yigzaw; T M Stringfield; T B Patel
Journal: Proc Natl Acad Sci U S A Date: 1999-08-17 Impact factor: 11.205

2. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells.

Authors: G E Aranda-Abreu; L Behar; S Chung; H Furneaux; I Ginzburg
Journal: J Neurosci Date: 1999-08-15 Impact factor: 6.167

Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases.

1. Isolation and characterization of a novel cardiac adenylylcyclase cDNA.

2. Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain.

3. A PCR procedure to determine the sequence of large polypeptides by rapid walking through a cDNA library.

Review 4. Guanylyl cyclases, a growing family of signal-transducing enzymes.

5. Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain.

6. The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes.

7. Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells.

8. Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation.

9. Two forms of the bovine brain Go that stimulate the inositol trisphosphate-mediated Cl- currents in Xenopus oocytes. Distinct guanine nucleotide binding properties.

10. Odorant signal termination by olfactory UDP glucuronosyl transferase.

1. Regions on adenylyl cyclase that are necessary for inhibition of activity by beta gamma and G(ialpha) subunits of heterotrimeric G proteins.

2. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells.

3. Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes.

4. Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase.

Review 5. Molecular details of cAMP generation in mammalian cells: a tale of two systems.

6. Regulation and immunohistochemical localization of betagamma-stimulated adenylyl cyclases in mouse hippocampus.

7. Streptozotocin-induced diabetes impairs G-protein linked signal transduction in vascular smooth muscle.

8. Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25.

Review 9. Regulation by Ca2+-signaling pathways of adenylyl cyclases.

Review 10. Adenylyl cyclases in the digestive system.