Literature DB >> 1409691

Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion.

C Gelpi1, E J Sontheimer, J L Rodriguez-Sanchez.   

Abstract

We describe an autoantibody specificity present in a subgroup of patients with a severe form of autoimmune chronic active hepatitis. These antibodies precipitate a 90-nucleotide RNA from human whole cell extracts and recognize a 48-kDa polypeptide in immunoblotting assays. The RNA is a UGA suppressor serine tRNA that carries selenocysteine (tRNA[Ser]Sec)), as shown by sequence analysis. The protein does not appear to be seryl-tRNA synthetase; rather, it is an excellent candidate for a factor involved in cotranslational selenocysteine incorporation in human cells.

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Year:  1992        PMID： 1409691      PMCID： PMC50208          DOI： 10.1073/pnas.89.20.9739

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  38 in total

1.  Use of in vitro 32P labeling in the sequence analysis of nonradioactive tRNAs.

Authors:  M Silberklang; A M Gillum; U L RajBhandary
Journal:  Methods Enzymol       Date:  1979       Impact factor: 1.600

Review 2.  Selenoprotein synthesis: an expansion of the genetic code.

Authors:  A Böck; K Forchhammer; J Heider; C Baron
Journal:  Trends Biochem Sci       Date:  1991-12       Impact factor: 13.807

3.  Autoantibodies to aminoacyl-transfer RNA synthetases for isoleucine and glycine. Two additional synthetases are antigenic in myositis.

Authors:  I N Targoff
Journal:  J Immunol       Date:  1990-03-01       Impact factor: 5.422

4.  Autoantibodies to intracellular antigens, with particular reference to transfer RNA and related proteins in myositis.

Authors:  R M Bernstein; M B Mathews
Journal:  J Rheumatol Suppl       Date:  1987-06

5.  A human opal suppressor tRNA gene and pseudogene.

Authors:  V A O'Neill; F C Eden; K Pratt; D L Hatfield
Journal:  J Biol Chem       Date:  1985-02-25       Impact factor: 5.157

Review 6.  Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states.

Authors:  C V Dang; C V Dang
Journal:  Mol Cell Biochem       Date:  1986-08       Impact factor: 3.396

7.  Cellular protein and RNA antigens in autoimmune disease.

Authors:  R M Bernstein; C C Bunn; G R Hughes; A M Francoeur; M B Mathews
Journal:  Mol Biol Med       Date:  1984-04

8.  Identification of three different anti-4S RNA sera associated with autoimmune disease.

Authors:  P Epstein; M Lidsky; R Reddy; E Tan; H Busch
Journal:  Biochem Biophys Res Commun       Date:  1982-11-30       Impact factor: 3.575

9.  Selenocysteine tRNA[Ser]Sec gene is ubiquitous within the animal kingdom.

Authors:  B J Lee; M Rajagopalan; Y S Kim; K H You; K B Jacobson; D Hatfield
Journal:  Mol Cell Biol       Date:  1990-05       Impact factor: 4.272

10.  A mammalian tRNAHis-containing antigen is recognized by the polymyositis-specific antibody anti-Jo-1.

Authors:  M D Rosa; J P Hendrick; M R Lerner; J A Steitz; M Reichlin
Journal:  Nucleic Acids Res       Date:  1983-02-11       Impact factor: 16.971
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  37 in total

1.  Autoantibody profiles in the sera of European patients with myositis.

Authors:  R Brouwer; G J Hengstman; W Vree Egberts; H Ehrfeld; B Bozic; A Ghirardello; G Grøndal; M Hietarinta; D Isenberg; J R Kalden; I Lundberg; H Moutsopoulos; P Roux-Lombard; J Vencovsky; A Wikman; H P Seelig; B G van Engelen ; W J van Venrooij
Journal:  Ann Rheum Dis       Date:  2001-02       Impact factor: 19.103

2.  Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine.

Authors:  F Ding; P J Grabowski
Journal:  RNA       Date:  1999-12       Impact factor: 4.942

Review 3.  Autoimmune hepatitis and its variant syndromes.

Authors:  Z Ben-Ari; A J Czaja
Journal:  Gut       Date:  2001-10       Impact factor: 23.059

4.  Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients withtype-1 autoimmune hepatitis.

Authors:  M Costa; J L Rodríguez-Sánchez; A J Czaja; C Gelpí
Journal:  Clin Exp Immunol       Date:  2000-08       Impact factor: 4.330

Review 5.  Advances in the current treatment of autoimmune hepatitis.

Authors:  Albert J Czaja
Journal:  Dig Dis Sci       Date:  2012-04-03       Impact factor: 3.199

Review 6.  Global Disparities and Their Implications in the Occurrence and Outcome of Autoimmune Hepatitis.

Authors:  Albert J Czaja
Journal:  Dig Dis Sci       Date:  2017-07-14       Impact factor: 3.199

Review 7.  Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease.

Authors:  Stefanie Gerstberger; Markus Hafner; Manuel Ascano; Thomas Tuschl
Journal:  Adv Exp Med Biol       Date:  2014       Impact factor: 2.622

8.  Reflex testing of speckled cytoplasmic patterns observed in routine ANA HEp-2 indirect immunofluorescence with a multiplex anti-synthetase dot-blot assay: a multicentric pilot study.

Authors:  Maria Infantino; Boaz Palterer; Roberta Biagiotti; Fabio Almerigogna; Maurizio Benucci; Arianna Damiani; Valentina Grossi; Annalisa Azzurri; Patrizia Casprini; Giovanni Bacci; Maria Grazia Giudizi; Mariangela Manfredi
Journal:  Immunol Res       Date:  2018-02       Impact factor: 2.829

9.  RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea.

Authors:  Jing Yuan; Sotiria Palioura; Juan Carlos Salazar; Dan Su; Patrick O'Donoghue; Michael J Hohn; Alexander Machado Cardoso; William B Whitman; Dieter Söll
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-01       Impact factor: 11.205

10.  The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation.

Authors:  Sotiria Palioura; R Lynn Sherrer; Thomas A Steitz; Dieter Söll; Miljan Simonovic
Journal:  Science       Date:  2009-07-17       Impact factor: 47.728
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