Literature DB >> 14075694

DRUG-INDUCED CHANGES IN THE LIVER ENDOPLASMIC RETICULUM: ASSOCIATION WITH DRUG-METABOLIZING ENZYMES.

H REMMER, H J MERKER.   

Abstract

The cellular changes which lead to the increase of drug-metabolizing enzymes following drug administration are explained by correlating new biochemical data with previously reported electron microscopic and pharmacologic observations. Repeated administration of phenobarbital and several other drugs results in a quantitative increase of the smooth endoplasmic reticulum of the liver cell. The marked increase in drug-metabolizing enzymes is found to occur in this enlarged smooth membrane fraction of the endoplasmic reticulum.

Entities:  

Keywords:  ADENOSINE TRIPHOSPHATASE; CYTOCHROMES; LIVER CYTOLOGY; LIVER ENZYMOLOGY; MEPROBAMATE; NIKETHAMIDE; NITROGEN; NUCLEOSIDASES; ORPHENADRINE; PHARMACOLOGY; PHENOBARBITAL; PHENYLBUTAZONE; PHOSPHATASES; PHOSPHORUS; TOLBUTAMIDE

Mesh：

Substances：

Year:  1963        PMID： 14075694     DOI： 10.1126/science.142.3600.1657

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  69 in total

Review 1.  [Structure and function of the endoplasmic reticulum].

Authors:  H U Schulze; H Staudinger
Journal:  Naturwissenschaften       Date:  1975-07

2.  [INCREASED GLUCURONIDATION OF SULFADIMETHOXINE DURING AND AFTER PHENOBARBITAL TREATMENT IN RATS].

Authors:  H REMMER
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1964-07-28

3.  [ACCELERATED DRUG DEGRADATION BY ENZYME INDUCTION IN DOGS AFTER TREATMENT WITH PHENOBARBITAL].

Authors:  H REMMER; M SIEGERT
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1964-07-28

4.  [INCREASE IN DRUG OXIDIZING ENZYME ACTIVITY WITH TOLBUTAMIDE].

Authors:  H REMMER; M SIEGERT; H J MERKER
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1964-10-02

5.  Rtn1p is involved in structuring the cortical endoplasmic reticulum.

Authors:  Johan-Owen De Craene; Jeff Coleman; Paula Estrada de Martin; Marc Pypaert; Scott Anderson; John R Yates; Susan Ferro-Novick; Peter Novick
Journal:  Mol Biol Cell       Date:  2006-04-19       Impact factor: 4.138

6.  Potentiation of the chemotherapeutic action of tegafur against solid adenocarcinoma 755 by combination with L-cystine.

Authors:  M Iigo; A Hoshi; H Kitagawa
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

7.  Vascular permeability in experimental kernicterus: an electron-microscopic study of the blood-brain barrier.

Authors:  H C Chen; C S Lin; I N Lien
Journal:  Am J Pathol       Date:  1967-07       Impact factor: 4.307

8.  Molecular cloning of a family of xenobiotic-inducible drosophilid cytochrome p450s: evidence for involvement in host-plant allelochemical resistance.

Authors:  P B Danielson; R J MacIntyre; J C Fogleman
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

9.  Studies on the lipid composition of the rat liver endoplasmic reticulum after induction with phenobarbitone and 20-methylcholanthrene.

Authors:  S C Davison; E D Wills
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857

10.  Phospholipid synthesis in rat liver endoplasmic reticulum after the administration of phenobarbitone and 20-methylcholanthrene.

Authors:  S C Davison; E D Wills
Journal:  Biochem J       Date:  1974-07       Impact factor: 3.857
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