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Literature DB >> 14069243

IMMUNE RESPONSE AND MITOSIS OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN VITRO.

K HIRSCHHORN, F BACH, R L KOLODNY, I L FIRSCHEIN, N HASHEM.

Abstract

Phytohemagglutinin causes cultured lymphocytes to agglutinate, divide, and produce gamma-globulin. Most cells are transformed into large lymphocytes, some resembling plasmocytes. Actinomycin D stops gamma-globulin production after 2 hours. When specific antigens are added to lymphocytes from sensitized individuals, only some cells undergo morphological transformation, produce gamma-globulin, and divide. When cells or cell extracts from an unrelated individual are added to a culture, a similar reaction occurs.

Entities: Chemical Species

Keywords: ACTINOMYCIN; ANTIGENS; CELL DIVISION; DIPHTHERIA TOXOID; EXPERIMENTAL LAB STUDY; LYMPHOCYTES; PENICILLIN; PERTUSSIS VACCINE; PHARMACOLOGY; PLANT AGGLUTININS; TUBERCULIN

Mesh：

Substances：

Year: 1963 PMID： 14069243 DOI： 10.1126/science.142.3596.1185

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

81 in total

1. THE ACTION OF STREPTOLYSIN S ON PERIPHERAL LYMPHOCYTES OF NORMAL SUBJECTS AND PATIENTS WITH ACUTE RHEUMATIC FEVER.

Authors: K HIRSCHHORN; R R SCHREIBMAN; S VERBO; R H GRUSKIN
Journal: Proc Natl Acad Sci U S A Date: 1964-11 Impact factor: 11.205

2. IN VITRO SECONDARY 19S AND 7S ANTIBODY RESPONSES TO POLIOVIRUS IN MEMBRANE CULTURES OF SEPARATED SPLEEN CELLS.

Authors: S E SVEHAG
Journal: Arch Gesamte Virusforsch Date: 1965

3. The cells involved in cell-mediated and transplantation immunity in the normal outbred rabbit. XIII. The identity of the responder cells and the role of phagocytic cells in the mixed leucocyte culture reaction.

Authors: N Lyscom; M Richter
Journal: Immunology Date: 1979-08 Impact factor: 7.397

IMMUNE RESPONSE AND MITOSIS OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN VITRO.

1. THE ACTION OF STREPTOLYSIN S ON PERIPHERAL LYMPHOCYTES OF NORMAL SUBJECTS AND PATIENTS WITH ACUTE RHEUMATIC FEVER.

2. IN VITRO SECONDARY 19S AND 7S ANTIBODY RESPONSES TO POLIOVIRUS IN MEMBRANE CULTURES OF SEPARATED SPLEEN CELLS.

3. The cells involved in cell-mediated and transplantation immunity in the normal outbred rabbit. XIII. The identity of the responder cells and the role of phagocytic cells in the mixed leucocyte culture reaction.

4. The blastogenic response of rabbit lymphocytes stimulated with autologous cells.

5. Further studies on the normal lymphocyte transfer test in man.

Review 6. Following the cytokine signaling pathway to leukemogenesis: a chronology.

Review 7. [Role of the lymphocyte transformation test in the evaluation of metal sensitization].

8. Recognition of a positive MLR within 4 hours using a carrier free electrophoresis system.

9. Replication of poliovirus in human lymphocytes stimulated with specific antigens.

10. DNA polymerase activity as an index of lymphocyte stimulation: studies in Down's syndrome.