Literature DB >> 14069241

MITOMYCIN C: CHEMICAL AND BIOLOGICAL STUDIES ON ALKYLATION.

H S SCHWARTZ, J E SODERGREN, F S PHILIPS.   

Abstract

The presence of an aziridine ring in mitomycin C suggests that the mechanism of action of the antibiotic is like that of the antitumor alkylating agents. However the compound is unexpectedly stable during aerobic incubation with rat liver homogenates although rapidly metabolized anaerobically. Mitomycin is not reactive with gamma-(4-nitrobenzyl) pyridine and reacts only slowly at acid p(H) with thiosulfate. It is proposed that mitomycin is activated in vivo, possibly by a reduction which "unmasks" the potential activity of the fused aziridine ring.

Entities:  

Keywords:  CHEMISTRY; EXPERIMENTAL LAB STUDY; LIVER; MITOMYCIN; PHARMACOLOGY; RATS

Mesh：

Substances：

Year:  1963        PMID： 14069241     DOI： 10.1126/science.142.3596.1181

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  16 in total

1.  Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae.

Authors:  P R August; M C Flickinger; D H Sherman
Journal:  J Bacteriol       Date:  1994-07       Impact factor: 3.490

2.  Amine prodrugs which utilize hydroxy amide lactonization. I. A potential redox-sensitive amide prodrug.

Authors:  K L Amsberry; R T Borchardt
Journal:  Pharm Res       Date:  1991-03       Impact factor: 4.200

Review 3.  Mutagenic effects of some anticancer antibiotics.

Authors:  B K Vig
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

4.  Generation of free radicals from phenazine methosulfate, streptonigrin, and riboflavin in bacterial suspensions.

Authors:  J R White; H H Dearman
Journal:  Proc Natl Acad Sci U S A       Date:  1965-09       Impact factor: 11.205

5.  Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair.

Authors:  Min Zhao; Dan-Dan Wang; Yuan Che; Meng-Qiu Wu; Qing-Ran Li; Chang Shao; Yun Wang; Li-Juan Cao; Guang-Ji Wang; Hai-Ping Hao
Journal:  Acta Pharmacol Sin       Date:  2017-08-24       Impact factor: 6.150

Review 6.  Targeting hypoxia in cancer therapy.

Authors:  William R Wilson; Michael P Hay
Journal:  Nat Rev Cancer       Date:  2011-06       Impact factor: 60.716

7.  NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

Authors:  N R Bachur; S L Gordon; M V Gee; H Kon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

8.  [Studies on combined cytostatic therapy. The effect of cyclophosphamide and mitomycin C on the cortisone degradation of the liver].

Authors:  L Lutzmann; C G Schmidt
Journal:  Klin Wochenschr       Date:  1965-11-15

9.  Position-specific effects in the mutagenic action of mitomycin C on the chromosomes of Hordeum vulgare L.

Authors:  K I Gecheff
Journal:  Theor Appl Genet       Date:  1989-05       Impact factor: 5.699

10.  Response variability of human brain tumors to AZQ in tissue culture.

Authors:  P L Kornblith; L Rosa; J D Bona; J A Edwards; N Matuzic; A Hirschfeld; C Hawkins
Journal:  J Neurooncol       Date:  1986       Impact factor: 4.130
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