Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Oxidative biotransformation of di-n-butylnitrosamine. Formation in vitro of aldehydes in the presence of rat liver microsomes.

Literature DB >> 140545

Oxidative biotransformation of di-n-butylnitrosamine. Formation in vitro of aldehydes in the presence of rat liver microsomes.

Abstract

After in vitro incubation of di-n-butylnitrosamine with rat liver microsomes in the presence of the necessary cofactors butyraldehyde has been identified as a reaction product together with smaller amounts of propionaldehyde and acetaldehyde.

Entities: Chemical Species

Mesh：

Substances：
Nitrosamines

Year: 1977 PMID： 140545 DOI： 10.1007/bf00305368

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

12 in total

1. Microsomal N-demethylation and the effect of the hepatic carcinogen dimethylnitrosamine on amino acid incorporation into the proteins of rat livers and hepatomas.

Authors: J A BROUWERS; P EMMELOT
Journal: Exp Cell Res Date: 1960-04 Impact factor: 3.905

2. Mechanism of carcinogenesis with 1-aryl-3,3-dialkyltriazenes. Enzymatic dealkylation by rat liver microsomal fraction in vitro.

Authors: R Preussmann; A von Hodenberg; H Hengy
Journal: Biochem Pharmacol Date: 1969-01 Impact factor: 5.858

3. [Structure of rat urinary metabolites of the carcinogen methyl-n-butyl-nitrosamine (author's transl)].

Authors: L Blattmann; N Joswig; R Preussmann
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1974-03-14

4. [Biotransformation of carcinogenic dialkylnitrosamines. Further urinary metabolites of di-n-butyl- and di-n-pentyl-nitrosamine (author's transl)].

Authors: L Blattmann; R Preussmann
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1974-03-14

5. [Structure of rat urinary metabolites of carcinogenic dialkylnitrosamines (author's transl)].

Authors: L Blattmann; R Preussmann
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1973

6. Rapid and selective induction of urinary bladder cancer in rats with N-ethyl-N-(4-hydroxybutyl)nitrosoamine and by its principal urinary metabolite.

Authors: Y Hashimoto; M Iiyoshi; M Okada
Journal: Gan Date: 1974-12

10. [Metabolism of nitrosamines in vivo. I. Evidence for -oxydation of aliphatic di-n-alkylnitrosamines: the stimultaneous formation of 7-methylguanine besides 7-propyl- or 7-butylguanine after application of di-n-propyl- or di-n-butylnitrosamine].

Authors: F W Krüger
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1971

1 in total

1. Direct alkyl chain cleavage after C-hydroxylation of dialkylnitrosamines in rats. A new pathway of the oxidative biotransformation.

Authors: L Blattmann
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1977