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Literature DB >> 124517

[Rat urinary metabolites of (2-hydroxybutyl)-n-butylnitrosamine].

Abstract

The chemical structure of 3 urinary metabolites of 2-hydroxy-di-n-butylnitrosamine has been identified by mass spectrometry. The results indicate that oxidation and formation of metabolites with shorter chain length may be explained by alpha-oxidation and subsequent degradation. This is an alternative to the beta-oxidation hypothesis of Krüger (1971).

Entities: Chemical Species

Mesh：

Substances：
Nitrosamines

Year: 1975 PMID： 124517 DOI： 10.1007/bf00282979

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

9 in total

1. Metabolism of nitrosamines in vivo. 3. On the methylation of nucleic acids by aliphatic Di-n-alkyl-nitrosamines in vivo resueting from heta-oxidation: the formation of 7-methylguanine after application of 2-oxo-propyl-propyl-nitrosamine and methyl-propyl-nitro-samine.

Authors: F W Krüger; B Bertram
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1973-12-06

2. [Structure of rat urinary metabolites of the carcinogen methyl-n-butyl-nitrosamine (author's transl)].

Authors: L Blattmann; N Joswig; R Preussmann
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1974-03-14

3. [Biotransformation of carcinogenic dialkylnitrosamines. Further urinary metabolites of di-n-butyl- and di-n-pentyl-nitrosamine (author's transl)].

Authors: L Blattmann; R Preussmann
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1974-03-14

4. Metabolism of nitrosamines in vivo. II. On the methylation of nucleic acids by aliphatic di-n-alkyl-nitrosamines in vivo, caused by beta-oxydation: the increased formation of 7-methyl-guanine after application of beta-hydroxypropyl-propyl-nitrosamine compared to that after application of di-n-propyl-nitrosamine.

Authors: F W Krüger
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1973

9. [Metabolism of nitrosamines in vivo. I. Evidence for -oxydation of aliphatic di-n-alkylnitrosamines: the stimultaneous formation of 7-methylguanine besides 7-propyl- or 7-butylguanine after application of di-n-propyl- or di-n-butylnitrosamine].

Authors: F W Krüger
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1971

9 in total

3 in total

1. Oxidative biotransformation of di-n-butylnitrosamine. Formation in vitro of aldehydes in the presence of rat liver microsomes.

Authors: L Blattmann; R Preussmann
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1977

2. Letter: Induction of tumours and bifunctional crosslinking metabolites of nitrosamines.

Authors: R Schoental
Journal: Br J Cancer Date: 1976-06 Impact factor: 7.640

3. Direct alkyl chain cleavage after C-hydroxylation of dialkylnitrosamines in rats. A new pathway of the oxidative biotransformation.

Authors: L Blattmann
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1977

3 in total

[Rat urinary metabolites of (2-hydroxybutyl)-n-butylnitrosamine].

1. Metabolism of nitrosamines in vivo. 3. On the methylation of nucleic acids by aliphatic Di-n-alkyl-nitrosamines in vivo resueting from heta-oxidation: the formation of 7-methylguanine after application of 2-oxo-propyl-propyl-nitrosamine and methyl-propyl-nitro-samine.

2. [Structure of rat urinary metabolites of the carcinogen methyl-n-butyl-nitrosamine (author's transl)].

3. [Biotransformation of carcinogenic dialkylnitrosamines. Further urinary metabolites of di-n-butyl- and di-n-pentyl-nitrosamine (author's transl)].

5. [Structure of rat urinary metabolites of carcinogenic dialkylnitrosamines (author's transl)].

6. Metabolism of butyl(4-hydroxybutyl)nitrosoamine in rats.

7. Alkylation of rat liver nucleic acids not related to carcinogenesis by N-nitrosamines.

8. Alkylation of rat liver RNA by cyclic N-nitrosamines in vivo.

9. [Metabolism of nitrosamines in vivo. I. Evidence for -oxydation of aliphatic di-n-alkylnitrosamines: the stimultaneous formation of 7-methylguanine besides 7-propyl- or 7-butylguanine after application of di-n-propyl- or di-n-butylnitrosamine].

1. Oxidative biotransformation of di-n-butylnitrosamine. Formation in vitro of aldehydes in the presence of rat liver microsomes.

2. Letter: Induction of tumours and bifunctional crosslinking metabolites of nitrosamines.

3. Direct alkyl chain cleavage after C-hydroxylation of dialkylnitrosamines in rats. A new pathway of the oxidative biotransformation.