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Literature DB >> 14014718

Lactate dehydrogenase variant from human blood: evidence for molecular subunits.

S H BOYER, D C FAINER, E J WATSON-WILLIAMS.

Abstract

A variant of human lactate dehydrogenase is described. The occurrence of lactate dehydrogenase-1, -2, -3, and -4 as five, four, three, and two components, respectively, is interpreted as supporting the hypothesis that LDH isozymes are tetramers formed from various combinations of two types of subunits.

Entities: Species

Keywords: LACTATE DEHYDROGENASE

Mesh：

Substances：

Year: 1963 PMID： 14014718 DOI： 10.1126/science.141.3581.642

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

20 in total

1. Evidence for the lack of feedback regulation of gene activity and for the absence of subunit exchange between lactate dehydrogenase tetramers in vivo.

Authors: B Nadal-Ginard
Journal: Proc Natl Acad Sci U S A Date: 1976-10 Impact factor: 11.205

2. [Distribution of the isoenzym lactatdehydrogenase in human cartilage (author's transl)].

Authors: G Weseloh; A Fiesselmann
Journal: Arch Orthop Unfallchir Date: 1975-12-22

3. [Genetics of bovine lactate dehydrogenase isoenzymes].

Authors: K Frahm; F Graf; H Kräußlich; L Furtmayr
Journal: Theor Appl Genet Date: 1977-03 Impact factor: 5.699

4. Two further cases of homozygosity for a lactate dehydrogenase variant gene.

Authors: N Saha; R L Kirk; J V Undevia
Journal: Am J Hum Genet Date: 1974-11 Impact factor: 11.025

5. The distribution of genetic polymorphisms among patients with Down's syndrome, phenylketonuria, and cystic fibrosis of the pancreas.

Authors: D Y Hsia; L Y Shih; S Easterberg; J Farquhar; C B Kim; S Yeh; A Young
Journal: Am J Hum Genet Date: 1969-05 Impact factor: 11.025

Lactate dehydrogenase variant from human blood: evidence for molecular subunits.

1. Evidence for the lack of feedback regulation of gene activity and for the absence of subunit exchange between lactate dehydrogenase tetramers in vivo.

2. [Distribution of the isoenzym lactatdehydrogenase in human cartilage (author's transl)].

3. [Genetics of bovine lactate dehydrogenase isoenzymes].

4. Two further cases of homozygosity for a lactate dehydrogenase variant gene.

5. The distribution of genetic polymorphisms among patients with Down's syndrome, phenylketonuria, and cystic fibrosis of the pancreas.

Review 6. [On the problem of assigning genes to definite human autosomes with the aid of chromosome aberrations].

7. Multiple lactate dehydrogenase alleles in the lizard Agama stellio.

8. A genetically determined variant of the A-subunit of lactic dehydrogenase in the deer mouse.

9. Patterns of enzyme development utilizing cultivated human fetal cells derived from amniotic fluid.

10. Developmental genetics of the esterase isozymes of Fundulus heteroclitus.