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Literature DB >> 13947640

Some neurochemical aspects of the depressant action of gamma-butyrolactone on the central nervous system.

Abstract

gamma-Butyrolactone, a depressant drug of the central nervous system, has been investigated for its ability to alter brain levels of 5-hydroxytryptamine, gamma-aminobutyric acid and acetylcholine in mice and rats; of these three compounds, only acetylcholine was changed in amount. Levels of acetylcholine in the cerebral cortex were increased by gamma-butyrolactone with a time-course which closely followed the depressed state of the animal. Indirect evidence has been presented to show that in the mid-brain and brain stem the change in acetylcholine level induced by gamma-butyrolactone is sharply localized in an area of the mesencephalon that contains the corpora quadrigemina.

Entities: Chemical Disease Species

Keywords: ACETYLCHOLINE; AMINO ACIDURIA; BRAIN; HYPNOTICS AND SEDATIVES; LACTONES; SEROTONIN

Mesh：

Substances：

Year: 1963 PMID： 13947640 PMCID： PMC1703811 DOI： 10.1111/j.1476-5381.1963.tb01493.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

14 in total

1. Drug-induced changes in brain acetylcholine.

Authors: N J GIARMAN; G PEPEU
Journal: Br J Pharmacol Chemother Date: 1962-10

2. Acquired porphyria.

Authors: R SCHMID
Journal: JAMA Date: 1963-01-12 Impact factor: 56.272

3. Structure-activity determinants of pharmacological effects of amino acids and related compounds on central synapses.

Authors: D P PURPURA; M GIRADO; T G SMITH; D A CALLAN; H GRUNDFEST
Journal: J Neurochem Date: 1959-01 Impact factor: 5.372

4. Effect of anticholinesterases on acetylcholine levels in insects.

Authors: B N SMALLMAN; R W FISHER
Journal: Can J Biochem Physiol Date: 1958-06

5. Identification and assay of serotonin in brain.

Authors: D F BOGDANSKI; A PLETSCHER; B B BRODIE; S UNDENFRIEND
Journal: J Pharmacol Exp Ther Date: 1956-05 Impact factor: 4.030

6. Drug-induced alterations in the sub-cellular distribution of 5-hydroxytryptamine in rats brain.

Authors: S M SCHANBERG; N J GIARMAN
Journal: Biochem Pharmacol Date: 1962-03 Impact factor: 5.858

7. The effect of anaesthesia on the acetylcholine content of brain.

Authors: J CROSSLAND; A J MERRICK
Journal: J Physiol Date: 1954-07-28 Impact factor: 5.182

8. Variation in acetylcholine content of the brain with physiological state.

Authors: D RICHTER; J CROSSLAND
Journal: Am J Physiol Date: 1949-11

9. Effects of drugs which depress the peripheral nervous system on the reticular activating system of the cat.

Authors: K A EXLEY; M C FLEMING; A D ESPELIEN
Journal: Br J Pharmacol Chemother Date: 1958-12

10. Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).

Authors: D P WALLACH
Journal: Biochem Pharmacol Date: 1961-02 Impact factor: 5.858

13 in total

1. Increase in brain dopamine after axotomy or treatment with gammahydroxybutyric acid due to elimination of the nerve impulse flow.

Authors: G Stock; T Magnusson; N E Andén
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

Some neurochemical aspects of the depressant action of gamma-butyrolactone on the central nervous system.

1. Drug-induced changes in brain acetylcholine.

2. Acquired porphyria.

3. Structure-activity determinants of pharmacological effects of amino acids and related compounds on central synapses.

4. Effect of anticholinesterases on acetylcholine levels in insects.

5. Identification and assay of serotonin in brain.

6. Drug-induced alterations in the sub-cellular distribution of 5-hydroxytryptamine in rats brain.

7. The effect of anaesthesia on the acetylcholine content of brain.

8. Variation in acetylcholine content of the brain with physiological state.

9. Effects of drugs which depress the peripheral nervous system on the reticular activating system of the cat.

10. Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).

1. Increase in brain dopamine after axotomy or treatment with gammahydroxybutyric acid due to elimination of the nerve impulse flow.

2. Gamma-hydroxybutyric acid and sleep.

3. Cardiovascular effects of intracerebroventricular GABA, glycine and muscimol in the rat.

4. Effect of anesthetic doses of gamma-hydroxybutyrate on the acetylcholine content of rat brain.

5. Failure of gamma-hydroxybutyrate to alter the function of the GABAA receptor complex in the rat cerebral cortex.

6. The effect of sodium -hydroxybutyrate on the metabolism of dopamine in the brain.

7. THE EXCITATION AND DEPRESSION OF MAMMALIAN CORTICAL NEURONES BY AMINO ACIDS.

8. Effects of gamma-hydroxybutyrate on chick behaviour, electrocortical activity and crossed extensor reflexes.

9. Evidence for down-regulation of GABA receptors following long-term gamma-butyrolactone.

10. Effect of -hydroxybutyrate on the release of monoamines from the rat striatum.