Literature DB >> 1386806

Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons.

H U Zeilhofer1, D Swandulla, G Geisslinger, K Brune.   

Abstract

The effects of R- and S-ketamine on N-methyl-D-aspartate receptor-activated cation currents (NMDA receptor currents) of voltage-clamped cultured rat hippocampal neurons were investigated using the whole-cell patch-clamp technique. Both enantiomers exhibited a voltage- and use-dependent blockade of NMDA receptor currents, with the S-enantiomer being about twice as potent as the R-enantiomer. Calculated relative forward and backward rates suggest that conformational differences influence the dissociation from the binding site more than the association with it.

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Year:  1992        PMID： 1386806     DOI： 10.1016/0014-2999(92)90248-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  27 in total

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2.  Ketamine impairs excitability in superficial dorsal horn neurones by blocking sodium and voltage-gated potassium currents.

Authors:  Rose Schnoebel; Matthias Wolff; Saskia C Peters; Michael E Bräu; Andreas Scholz; Gunter Hempelmann; Horst Olschewski; Andrea Olschewski
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Review 3.  Antidepressant Efficacy and Tolerability of Ketamine and Esketamine: A Critical Review.

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Review 4.  Using EEG to monitor anesthesia drug effects during surgery.

Authors:  Leslie C Jameson; Tod B Sloan
Journal:  J Clin Monit Comput       Date:  2006-12       Impact factor: 2.502

Review 5.  Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia.

Authors:  Andrea Kopp Lugli; Charles Spencer Yost; Christoph H Kindler
Journal:  Eur J Anaesthesiol       Date:  2009-10       Impact factor: 4.330

Review 6.  General anesthetics and molecular mechanisms of unconsciousness.

Authors:  Stuart A Forman; Victor A Chin
Journal:  Int Anesthesiol Clin       Date:  2008

7.  Hydroxynorketamine Blocks N-Methyl-d-Aspartate Receptor Currents by Binding to Closed Receptors.

Authors:  Jamie A Abbott; Gabriela K Popescu
Journal:  Mol Pharmacol       Date:  2020-06-29       Impact factor: 4.436

8.  Reply to: Rapid antidepressant effects and abuse liability of ketamine.

Authors:  Todd M Hillhouse; Joseph H Porter; S Stevens Negus
Journal:  Psychopharmacology (Berl)       Date:  2014-05       Impact factor: 4.530

9.  Acute ketamine challenge increases resting state prefrontal-hippocampal connectivity in both humans and rats.

Authors:  Oliver Grimm; Natalia Gass; Wolfgang Weber-Fahr; Alexander Sartorius; Esther Schenker; Michael Spedding; Celine Risterucci; Janina Isabel Schweiger; Andreas Böhringer; Zhenxiang Zang; Heike Tost; Adam James Schwarz; Andreas Meyer-Lindenberg
Journal:  Psychopharmacology (Berl)       Date:  2015-07-18       Impact factor: 4.530

10.  Comparing caudal and intravenous ketamine for supplementation of analgesia after Salter innominate osteotomy.

Authors:  Hamid Reza Amiri; Ramin Espandar; Mehdi Sanatkar
Journal:  J Child Orthop       Date:  2012-11-16       Impact factor: 1.548
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