OBJECTIVE: To evaluate correlations between changes in anti-U1 RNA antibody levels and disease activity in 9 patients with systemic lupus erythematosus (SLE) overlap syndrome who were prospectively followed up for at least 3 years. METHODS: Anti-U1 RNA antibody levels were measured quantitatively, using a nitrocellulose filter binding assay. Disease activity was measured with a validated SLE activity index. RESULTS: All 9 major disease exacerbations were associated with peaks in anti-U1 RNA antibody level. CONCLUSION: These results seem to indicate that measuring anti-U1 RNA antibody levels can be useful for monitoring disease activity.
OBJECTIVE: To evaluate correlations between changes in anti-U1 RNA antibody levels and disease activity in 9 patients with systemic lupus erythematosus (SLE) overlap syndrome who were prospectively followed up for at least 3 years. METHODS: Anti-U1 RNA antibody levels were measured quantitatively, using a nitrocellulose filter binding assay. Disease activity was measured with a validated SLE activity index. RESULTS: All 9 major disease exacerbations were associated with peaks in anti-U1 RNA antibody level. CONCLUSION: These results seem to indicate that measuring anti-U1 RNA antibody levels can be useful for monitoring disease activity.
Authors: D Villalta; N Bizzaro; S Platzgummer; A Antico; M Tampoia; L Camogliano; D Bassetti; M Pradella; A Piazza; F Manoni; R Tozzoli; E Tonutti Journal: Clin Rheumatol Date: 2004-12-10 Impact factor: 2.980
Authors: A Guialis; M Patrinou-Georgoula; N Tsifetaki; V Aidinis; C E Sekeris; H M Moutsopoulos Journal: Clin Exp Immunol Date: 1994-03 Impact factor: 4.330