Literature DB >> 12626463

Nucleoporin p62 antibodies in a case of mixed connective tissue disease.

Doris M Kraemer1, Michael R Kraus, Christian Kneitz, Hans-Peter Tony.   

Abstract

Mixed connective tissue disease is an overlap syndrome characterized by features of different systemic autoimmune diseases and a high titer of U1-snRNP antibodies. We examine here the autoantibodies to nucleoporin p62 in a severe case of mixed connective tissue disease in a young male patient. Thus far, p62 antibodies have mainly been described in cases of primary biliary cirrhosis. We speculate that the presence of p62 antibodies is an indication of a poor prognosis in connective tissue disorders.

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Year:  2003        PMID： 12626463      PMCID： PMC150528          DOI： 10.1128/cdli.10.2.329-331.2003

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  11 in total

Review 1.  Anti-nuclear envelope antibodies: Clinical associations.

Authors:  G Nesher; R Margalit; Y J Ashkenazi
Journal:  Semin Arthritis Rheum       Date:  2001-04       Impact factor: 5.532

Review 2.  Mixed connective tissue disease.

Authors:  R Kasukawa
Journal:  Intern Med       Date:  1999-05       Impact factor: 1.271

3.  Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis.

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Journal:  J Hepatol       Date:  2001-03       Impact factor: 25.083

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Authors:  M Stewart; W D Clarkson
Journal:  Curr Opin Struct Biol       Date:  1996-04       Impact factor: 6.809

5.  Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway.

Authors:  L I Davis; G Blobel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

6.  Changes in anti-U1 RNA antibody levels correlate with disease activity in patients with systemic lupus erythematosus overlap syndrome.

Authors:  R M Hoet; I Koornneef; D J de Rooij; L B van de Putte; W J van Venrooij
Journal:  Arthritis Rheum       Date:  1992-10

7.  Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization.

Authors:  M Carmo-Fonseca; H Kern; E C Hurt
Journal:  Eur J Cell Biol       Date:  1991-06       Impact factor: 4.492

8.  Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis.

Authors:  J Wesierska-Gadek; H Hohenuer; E Hitchman; E Penner
Journal:  Gastroenterology       Date:  1996-03       Impact factor: 22.682

9.  A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma.

Authors:  J Y Zhang; E K Chan; X X Peng; E M Tan
Journal:  J Exp Med       Date:  1999-04-05       Impact factor: 14.307

10.  Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA.

Authors:  A Radu; G Blobel; R W Wozniak
Journal:  J Cell Biol       Date:  1993-04       Impact factor: 10.539
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  5 in total

Review 1.  Primary biliary cirrhosis and the nuclear pore complex.

Authors:  Carolina Duarte-Rey; Dimitrios Bogdanos; Chen-Yen Yang; Krista Roberts; Patrick S C Leung; Juan-Manuel Anaya; Howard J Worman; M Eric Gershwin
Journal:  Autoimmun Rev       Date:  2012-04-01       Impact factor: 9.754

2.  The nuclear pore complex protein Tpr is a common autoantigen in sera that demonstrate nuclear envelope staining by indirect immunofluorescence.

Authors:  Y Ou; P Enarson; J B Rattner; S G Barr; M J Fritzler
Journal:  Clin Exp Immunol       Date:  2004-05       Impact factor: 4.330

Review 3.  Autoantigens of the nuclear pore complex.

Authors:  P Enarson; J B Rattner; Y Ou; K Miyachi; T Horigome; M J Fritzler
Journal:  J Mol Med (Berl)       Date:  2004-06-03       Impact factor: 4.599

4.  Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus.

Authors:  Doris M Kraemer; Hans-Peter Tony
Journal:  Open Rheumatol J       Date:  2010-05-13

5.  An autoimmune myositis-overlap syndrome associated with autoantibodies to nuclear pore complexes: description and long-term follow-up of the anti-Nup syndrome.

Authors:  Jean-Luc Senécal; Catherine Isabelle; Marvin J Fritzler; Ira N Targoff; Rose Goldstein; Michel Gagné; Jean-Pierre Raynauld; France Joyal; Yves Troyanov; Marie-Christine Dabauvalle
Journal:  Medicine (Baltimore)       Date:  2014-11       Impact factor: 1.889
  5 in total

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