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Literature DB >> 138280

[Nitrosamin induced neoplasms of the colon and rectum. Investigations on the morphogenesis in rats (author's transl)].

Abstract

The morphogenesis of neoplasms (carcinomas and pracecancerous polypoid lesions) induced by N-methyl-N-nitroso-N'-nitroguanidine (MNNG) was studied on 154 male Wistar rats (including controls), from which a group received a colostomy. Operated and non-operated rats were treated by intrarectal instillations of 2 mg per kg body weight MNNG twice a week during a period of 210 days.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1976 PMID： 138280 DOI： 10.1007/bf00506507

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

31 in total

1. CARCINOGENIC EFFECTS OF CYCAD MEAL AND CYCASIN, METHYLAZOXYMETHANOL GLYCOSIDE, IN RATS AND EFFECTS OF CYCASIN IN GERMFREE RATS.

Authors: G L LAQUEUR
Journal: Fed Proc Date: 1964 Nov-Dec

2. Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats.

Authors: J M Ward
Journal: Lab Invest Date: 1974-04 Impact factor: 5.662

3. The geographic pathology of bowel cancer.

Authors: J W Berg; M A Howell
Journal: Cancer Date: 1974-09 Impact factor: 6.860

4. President's address. The polyp-cancer sequence in the large bowel.

Authors: B Morson
Journal: Proc R Soc Med Date: 1974-06

5. Induction of carcinomas of the colon and rectum in rats by intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine.

Authors: B T So; N E Magadia; E L Wynder
Journal: J Natl Cancer Inst Date: 1973-04 Impact factor: 13.506

6. The induction of intestinal neoplasms in rats with the glycoside cycasin and its aglycone.

Authors: G L Laqueur
Journal: Virchows Arch Pathol Anat Physiol Klin Med Date: 1965-12-21

7. Production of tumors in glandular stomach of hamsters by N-methyl-N'-nitro-N-nitrosoguanidine.

Authors: S Fujimura; K Kogure; S Oboshi; T Sugimura
Journal: Cancer Res Date: 1970-05 Impact factor: 12.701

8. Carcinoma of the colon and rectum of rats by rectal infusion of N-methyl-N'-nitro-N-nitrosoguanidine.

Authors: T Narisawa; T Sato; M Hayakawa; A Sakuma; H Nakano
Journal: Gan Date: 1971-06

9. Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice.

Authors: B Wiebecke; U Krey; U Löhrs; M Eder
Journal: Virchows Arch A Pathol Pathol Anat Date: 1973-09-04