| Literature DB >> 1381211 |
L T Soh1, P T Ang, I Sng, E J Chua, Y W Ong.
Abstract
Chemotherapy is the mainstay of therapy for patients with non-Hodgkin lymphoma. Among side-effects associated with the use of chemotherapy, immunosuppression is one which can be potentially fatal. In hepatitis B carriers, immunosuppression permits widespread infection of the hepatocytes and its subsequent withdrawal causes an "immunological rebound" leading to massive necrosis of hepatocytes. 4 patients who died of fulminant hepatitis following chemotherapy are reported. These were patients with positive hepatitis B serology. Caution is advised when treating non-Hodgkin lymphoma in patients from hepatitis B endemic regions.Entities:
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Year: 1992 PMID: 1381211 DOI: 10.1016/0959-8049(92)90513-2
Source DB: PubMed Journal: Eur J Cancer ISSN: 0959-8049 Impact factor: 9.162