| Literature DB >> 1380898 |
Abstract
Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA:RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion.Entities:
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Year: 1992 PMID: 1380898 DOI: 10.1007/bf00047600
Source DB: PubMed Journal: Cancer Metastasis Rev ISSN: 0167-7659 Impact factor: 9.264