Literature DB >> 1379716

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

C J Lowenstein1, C S Glatt, D S Bredt, S H Snyder.   

Abstract

Nitric oxide (NO) is a messenger molecule of macrophages, endothelial cells in blood vessels, and neurons. A neuronal form of NO synthase (NOS) has been previously cloned. We now report the molecular cloning of macrophage NOS. The macrophage enzyme displays 50% sequence identity to the neuronal enzyme. Like neuronal NOS, macrophage NOS has recognition sites for FAD, FMN, and NADPH and also has a consensus calmodulin binding site. Macrophage NOS mRNA is strikingly inducible; it is absent in quiescent macrophages or spleen but is prominent 2-6 hr after endotoxin treatment.

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Year:  1992        PMID： 1379716      PMCID： PMC49573          DOI： 10.1073/pnas.89.15.6711

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  54 in total

1.  Purification of nitric oxide synthase from rat macrophages.

Authors:  Y Yui; R Hattori; K Kosuga; H Eizawa; K Hiki; C Kawai
Journal:  J Biol Chem       Date:  1991-07-05       Impact factor: 5.157

Review 2.  Role of nitric oxide synthesis in macrophage antimicrobial activity.

Authors:  C F Nathan; J B Hibbs
Journal:  Curr Opin Immunol       Date:  1991-02       Impact factor: 7.486

3.  Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.

Authors:  D S Bredt; P M Hwang; C E Glatt; C Lowenstein; R R Reed; S H Snyder
Journal:  Nature       Date:  1991-06-27       Impact factor: 49.962

4.  Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

Authors:  D J Stuehr; H J Cho; N S Kwon; M F Weise; C F Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

Review 5.  Nitric oxide: physiology, pathophysiology, and pharmacology.

Authors:  S Moncada; R M Palmer; E A Higgs
Journal:  Pharmacol Rev       Date:  1991-06       Impact factor: 25.468

6.  Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse.

Authors:  J P Nowicki; D Duval; H Poignet; B Scatton
Journal:  Eur J Pharmacol       Date:  1991-11-12       Impact factor: 4.432

7.  Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

Authors:  J M Hevel; K A White; M A Marletta
Journal:  J Biol Chem       Date:  1991-12-05       Impact factor: 5.157

8.  Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.

Authors:  N S Kwon; C F Nathan; D J Stuehr
Journal:  J Biol Chem       Date:  1989-12-05       Impact factor: 5.157

9.  Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase.

Authors:  B Mayer; M John; B Heinzel; E R Werner; H Wachter; G Schultz; E Böhme
Journal:  FEBS Lett       Date:  1991-08-19       Impact factor: 4.124

10.  Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo.

Authors:  M A Dwyer; D S Bredt; S H Snyder
Journal:  Biochem Biophys Res Commun       Date:  1991-05-15       Impact factor: 3.575
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  115 in total

1.  IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages.

Authors:  C Contursi; I M Wang; L Gabriele; M Gadina; J O'Shea; H C Morse; K Ozato
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

Review 2.  Nitric oxide and bone.

Authors:  R J van't Hof; S H Ralston
Journal:  Immunology       Date:  2001-07       Impact factor: 7.397

3.  Expression of endothelial nitric oxide synthase in the porcine oocyte and its possible function.

Authors:  M A Hattori; K Takesue; Y Kato; N Fujihara
Journal:  Mol Cell Biochem       Date:  2001-03       Impact factor: 3.396

4.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1992-11-25       Impact factor: 16.971

5.  Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice.

Authors:  Roland Zell; René Markgraf; Michaela Schmidtke; Matthias Görlach; Axel Stelzner; Andreas Henke; Holger H Sigusch; Brigitte Glück
Journal:  Med Microbiol Immunol       Date:  2003-09-26       Impact factor: 3.402

6.  Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation.

Authors:  O Goureau; M Lepoivre; F Becquet; Y Courtois
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

7.  In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

Authors:  H Koprowski; Y M Zheng; E Heber-Katz; N Fraser; L Rorke; Z F Fu; C Hanlon; B Dietzschold
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

8.  Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

Authors:  D A Geller; C J Lowenstein; R A Shapiro; A K Nussler; M Di Silvio; S C Wang; D K Nakayama; R L Simmons; S H Snyder; T R Billiar
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

9.  Tyrosine kinase-dependent and -independent events induced by interleukin-2 stimulation: interleukin-2-mediated NO production required for the induction of lymphokine-activated killer cell activity in rat splenocytes is tyrosine kinase independent.

Authors:  A Juretic; G C Spagnoli; H Hörig; R Shipman; T Kocher; M Samija; M Turic; D Eljuga; F Harder; M Heberer
Journal:  Immunology       Date:  1995-06       Impact factor: 7.397

10.  Purification and characterization of nitric oxide synthase (NOSNoc) from a Nocardia species.

Authors:  Y Chen; J P Rosazza
Journal:  J Bacteriol       Date:  1995-09       Impact factor: 3.490
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