Literature DB >> 1712077

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.

D S Bredt1, P M Hwang, C E Glatt, C Lowenstein, R R Reed, S H Snyder.   

Abstract

Nitric oxide is a messenger molecule, mediating the effect of endothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors. The only known mammalian enzyme with close homology is cytochrome P-450 reductase.

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Year:  1991        PMID： 1712077     DOI： 10.1038/351714a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  389 in total

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