Literature DB >> 1379577

Inhibition of heat inactivation of reverse transcriptase of human immunodeficiency virus type 1 by seropositive sera.

T Nagumo1, Y Takeuchi, H Hoshino.   

Abstract

The reverse transcriptase (RT) activity of a lysate of human immunodeficiency virus type 1 (HIV) was almost completely inactivated by incubation at 56 degrees C for 20-30 min. The heat-inactivation of RT in the virus lysate or purified RT was partially inhibited in the presence of some human sera or plasma containing antibodies against HIV. The IgG fraction purified from the seropositive sera was responsible for stabilization of RT upon heat inactivation. This is a new assay system for detection of antibodies against RT.

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Year:  1992        PMID： 1379577      PMCID： PMC5918888          DOI： 10.1111/j.1349-7006.1992.tb00131.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  24 in total

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Authors:  A Chandra; T Gerber; P Chandra
Journal:  FEBS Lett       Date:  1986-03-03       Impact factor: 4.124

2.  Immunogenic nature of a Pol gene product of HTLV-III/LAV.

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Journal:  Blood       Date:  1987-01       Impact factor: 22.113

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Journal:  J Natl Cancer Inst       Date:  1972-09       Impact factor: 13.506

4.  Establishment and characterization of a human histiocytic lymphoma cell line (U-937).

Authors:  C Sundström; K Nilsson
Journal:  Int J Cancer       Date:  1976-05-15       Impact factor: 7.396

5.  Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients.

Authors:  W G Robey; B Safai; S Oroszlan; L O Arthur; M A Gonda; R C Gallo; P J Fischinger
Journal:  Science       Date:  1985-05-03       Impact factor: 47.728

6.  Inactivation of lymphocyte-transforming activity of human T-cell leukemia virus type I by heat.

Authors:  K Yamato; H Taguchi; S Yoshimoto; M Fujishita; M Yamashita; Y Ohtsuki; H Hoshino; I Miyoshi
Journal:  Jpn J Cancer Res       Date:  1986-01

7.  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.

Authors:  B J Poiesz; F W Ruscetti; A F Gazdar; P A Bunn; J D Minna; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

8.  Characterization and clinical association of antibody inhibitory to HIV reverse transcriptase activity.

Authors:  J Laurence; A Saunders; J Kulkosky
Journal:  Science       Date:  1987-03-20       Impact factor: 47.728

9.  Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.

Authors:  R C Gallo; S Z Salahuddin; M Popovic; G M Shearer; M Kaplan; B F Haynes; T J Palker; R Redfield; J Oleske; B Safai
Journal:  Science       Date:  1984-05-04       Impact factor: 47.728

10.  Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.

Authors:  J A Levy; A D Hoffman; S M Kramer; J A Landis; J M Shimabukuro; L S Oshiro
Journal:  Science       Date:  1984-08-24       Impact factor: 47.728
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  1 in total

1.  Characteristics and clinical significance of a stabilization assay to detect specific antibodies to reverse transcriptase of human immunodeficiency virus.

Authors:  M Morita; T Suzuki; K Nakajima; C Shiozawa; M J Gill; H Hoshino
Journal:  Clin Diagn Lab Immunol       Date:  1995-09
  1 in total

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