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Literature DB >> 1379391

Localization of the virus neutralizing and hemagglutinin epitopes of E1 glycoprotein of rubella virus.

H Chaye¹, P Chong, B Tripet, B Brush, S Gillam.

Abstract

Current serological assays using whole rubella virus (RV) as a target antigen for detecting RV-specific antibodies fail to define specific RV proteins and antigenic determinants such as hemagglutinin (HA) and virus-neutralizing (VN) epitopes of rubella virus. A panel of E1 deletion mutants and a subset of E1-specific monoclonal antibodies (MAb) were used for the initial analysis of HA and VN epitopes of E1 glycoprotein. A peptide region (E1(193) to E1(269)) was found to contain HA and VN epitopes. Using both overlapping synthetic peptides and truncated fusion proteins within this region, the HA epitope defined by MAb 3D9F mapped to amino acid residues E1(214) to E1(240), while two VN epitopes defined by MAb 21B9H and MAb 16A10E mapped to amino acid residues E1(214) to E1(233) and E1(219) to E1(233), respectively. The epitopes defined in this study are recognized by antibody whether or not the epitopes are glycosylated.

Entities: Chemical Disease Gene Species

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Year: 1992 PMID： 1379391 PMCID： PMC7172486 DOI： 10.1016/0042-6822(92)90572-7

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616

34 in total

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12 in total

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Authors: J Y Lee; D S Bowden
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Authors: Z Qiu; D Ou; T C Hobman; S Gillam
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5. Human T- and B-cell epitopes of E1 glycoprotein of rubella virus.

Authors: H Chaye; D Ou; P Chong; S Gillam
Journal: J Clin Immunol Date: 1993-03 Impact factor: 8.317

6. Rubella virus-specific cytotoxic T-lymphocyte responses: identification of the capsid as a target of major histocompatibility complex class I-restricted lysis and definition of two epitopes.

Authors: A E Lovett; C S Hahn; C M Rice; T K Frey; J S Wolinsky
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