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Literature DB >> 1377367

RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme.

Abstract

In catalysis by group I introns, the helix (P1) containing the RNA cleavage site must be positioned next to the guanosine binding site. We have identified a conserved adenine in the catalytic core that contributes to the stability of this arrangement and propose that it accepts a hydrogen bond from a specific 2'-OH in P1. Such base-backbone tertiary interactions may be generally important to the organization of RNA tertiary structure.

Entities: Chemical

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Year: 1992 PMID： 1377367 DOI： 10.1038/358123a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

43 in total

1. The fidelity of template-directed oligonucleotide ligation and the inevitability of polymerase function.

Authors: K D James; A D Ellington
Journal: Orig Life Evol Biosph Date: 1999-08 Impact factor: 1.950

2. An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site.

Authors: A A Szewczak; L Ortoleva-Donnelly; M V Zivarts; A K Oyelere; A V Kazantsev; S A Strobel
Journal: Proc Natl Acad Sci U S A Date: 1999-09-28 Impact factor: 11.205

3. Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron.

Authors: Aya Kitamura; Yutaka Muto; Satoru Watanabe; Insil Kim; Takuhiro Ito; Yoichi Nishiya; Kensaku Sakamoto; Takashi Ohtsuki; Gota Kawai; Kimitsuna Watanabe; Kazumi Hosono; Hiroshi Takaku; Etsuko Katoh; Toshimasa Yamazaki; Tan Inoue; Shigeyuki Yokoyama
Journal: RNA Date: 2002-04 Impact factor: 4.942

4. Assembly of core helices and rapid tertiary folding of a small bacterial group I ribozyme.

Authors: Prashanth Rangan; Benoît Masquida; Eric Westhof; Sarah A Woodson
Journal: Proc Natl Acad Sci U S A Date: 2003-02-06 Impact factor: 11.205

5. Monitoring intermediate folding states of the td group I intron in vivo.

Authors: Christina Waldsich; Benoît Masquida; Eric Westhof; Renée Schroeder
Journal: EMBO J Date: 2002-10-01 Impact factor: 11.598

6. Synthesis of 2'-N-methylamino-2'-deoxyguanosine and 2'-N,N-dimethylamino-2'-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry.

Authors: Qing Dai; Raghuvir Sengupta; Shirshendu K Deb; Joseph A Piccirilli
Journal: J Org Chem Date: 2011-10-03 Impact factor: 4.354

RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme.

1. The fidelity of template-directed oligonucleotide ligation and the inevitability of polymerase function.

2. An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site.

3. Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron.

4. Assembly of core helices and rapid tertiary folding of a small bacterial group I ribozyme.

5. Monitoring intermediate folding states of the td group I intron in vivo.

6. Synthesis of 2'-N-methylamino-2'-deoxyguanosine and 2'-N,N-dimethylamino-2'-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry.

7. Communication between RNA folding domains revealed by folding of circularly permuted ribozymes.

8. The chemical basis of adenosine conservation throughout the Tetrahymena ribozyme.

9. Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing.

10. Lead cleavage sites in the core structure of group I intron-RNA.