Literature DB >> 13769274

Rapid development of drug-resistant mutants of poliovirus.

J L MELNICK, D CROWTHER, J BARRERA-ORO.   

Abstract

Guanidine hydrochloride is a potent inhibitor of poliovirus synthesis in cell culture. However, the viral progeny which do grow in the presence of guani-dine may become approximately 10,000 times more resistant to the drug. The phenomenon of drug resistance poses yet another problem in the search for a satisfactory viral chemotherapeutic agent.

Entities:  

Keywords:  AMIDINES/pharmacology; POLIOMYELITIS VIRUSES/pharmacology

Mesh：

Substances：

Year:  1961        PMID： 13769274     DOI： 10.1126/science.134.3478.557

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

1.  CHARACTERS OF GUANIDINE RESISTANT MUTANTS OF TYPE 1 POLIOVIRUS.

Authors:  F HORODNICEANU; D SERGIESCU; R KLEIN; M ZAMFIRESCU; A A COMBIESCU
Journal:  Arch Gesamte Virusforsch       Date:  1964

2.  RESCUE OF DRUG-REQUIRING AND DRUG-INHIBITED ENTEROVIRUSES.

Authors:  N IKEGAMI; H J EGGERS; I TAMM
Journal:  Proc Natl Acad Sci U S A       Date:  1964-12       Impact factor: 11.205

3.  Poliovirus-induced RNA polymerase and the effects of virus-specific inhibitors on its production.

Authors:  D BALTIMORE; H J EGGERS; R M FRANKLIN; I TAMM
Journal:  Proc Natl Acad Sci U S A       Date:  1963-06       Impact factor: 11.205

Review 4.  Viral quasispecies evolution.

Authors:  Esteban Domingo; Julie Sheldon; Celia Perales
Journal:  Microbiol Mol Biol Rev       Date:  2012-06       Impact factor: 11.056

5.  Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance.

Authors:  Ron Geller; Marco Vignuzzi; Raul Andino; Judith Frydman
Journal:  Genes Dev       Date:  2007-01-15       Impact factor: 11.361

6.  Adsorption of enteroviruses to soil cores and their subsequent elution by artificial rainwater.

Authors:  E F Landry; J M Vaughn; M Z Thomas; C A Beckwith
Journal:  Appl Environ Microbiol       Date:  1979-10       Impact factor: 4.792

Review 7.  Genetic conflicts: the usual suspects and beyond.

Authors:  Richard N McLaughlin; Harmit S Malik
Journal:  J Exp Biol       Date:  2017-01-01       Impact factor: 3.312

8.  Antiviral action of gliotoxin.

Authors:  J K McDougall
Journal:  Arch Gesamte Virusforsch       Date:  1969

9.  Selection of variants of rhinoviruses.

Authors:  J E Acornley; P J Chapple; E J Stott; D A Tyrrell
Journal:  Arch Gesamte Virusforsch       Date:  1968

10.  Differences in multiplication of virulent and vaccine strains of poliovirus type I, II, and III in laboratory animals.

Authors:  G A Koroleva; V A Lashkevich; M K Voroshilova
Journal:  Arch Virol       Date:  1977       Impact factor: 2.574
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