| Literature DB >> 1376603 |
Abstract
Two related features of Ly-1+ B cells (CD5+ B cells in man) are their biased specificities and variable gene usage, and their relationship to the bulk of Ly-1- ('conventional') B cells. An emerging model views Ly-1+ B cells as a memory population in the adult animal, whose generation is largely limited to fetal and neonatal development. Selection based on germline-encoded self-reactivity then shapes the adult repertoire.Entities:
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Year: 1992 PMID: 1376603 DOI: 10.1016/0952-7915(92)90010-c
Source DB: PubMed Journal: Curr Opin Immunol ISSN: 0952-7915 Impact factor: 7.486