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Literature DB >> 13758290

Mast cell degranulation and histamine release observed in a new in vitro system.

Abstract

A method is described by which mast cells harvested from the rat peritoneal cavity can be deposited on the surface of a Millipore filter without gross injury, permitting observation of morphological and chemical changes induced by a variety of agents. These isolated peritoneal mast cells respond to 48/80 and to polymyxin B but not to dextran or ovomucoid with degranulation and histamine release. Thus four agents which in vivo appear to have similar activities have been found by means of in vitro analysis to operate by at least two different mechanisms.

Entities: Chemical Disease Species

Keywords: HISTAMINE; MAST CELLS/physiology

Mesh：

Substances：
Histamine

Year: 1960 PMID： 13758290 PMCID： PMC2137246 DOI： 10.1084/jem.112.4.571

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

16 in total

1. 5-Hydroxytryptophan decarboxylase activity in rat mast cells.

Authors: D LAGUNOFF; E P BENDITT
Journal: Am J Physiol Date: 1959-05

2. Studies of the mechanism of acute vascular reactions to injury. I. The relationship of mast cells and histamine to the production of edema by ovomucoid in rats.

Authors: E P BENDITT; S BADER; K B LAM
Journal: AMA Arch Pathol Date: 1955-07

8. Fractionation of the smooth muscle stimulants present in extracts of gastro-intestinal tract. Identification of 5-hydroxytryptamine and its distinction from substance P.

Authors: C E DALGLIESH; C C TOH; T S WORK
Journal: J Physiol Date: 1953-05-28 Impact factor: 5.182

9. 5-Hydroxytryptamine and histamine as mediators of the vascular injury produced by agents which damage mast cells in rats.

Authors: D A ROWLEY; E P BENDITT
Journal: J Exp Med Date: 1956-04-01 Impact factor: 14.307

Mast cell degranulation and histamine release observed in a new in vitro system.

1. 5-Hydroxytryptophan decarboxylase activity in rat mast cells.

2. Studies of the mechanism of acute vascular reactions to injury. I. The relationship of mast cells and histamine to the production of edema by ovomucoid in rats.

3. Isolation of "biologically intact" mast cells.

4. Application of millipore filtration technique to cytologic material.

5. 5-Hydroxytryptamine in mast cells.

6. Influence of various agents on mast cells isolated from rat peritoneal fluid.

7. A method for concentrating cancer cells suspended in large quantities of fluid.

8. Fractionation of the smooth muscle stimulants present in extracts of gastro-intestinal tract. Identification of 5-hydroxytryptamine and its distinction from substance P.

9. 5-Hydroxytryptamine and histamine as mediators of the vascular injury produced by agents which damage mast cells in rats.

10. An enzyme in mast cells with properties like chymotrypsin.

1. The uptake of amino acids and the synthesis of amines by neoplastic mast cells in culture.

2. [Electron microscopic observations on mast cell degranulation in diffuse mastocytosis in man].

3. Separation of mast cells from the peritoneal fluid of the rat with a GE nucleopore filter.

4. Protective effect of disodium cromoglycate on rat peritoneal mast cells.

5. The measurement of histamine release from suspensions of rat peritoneal cells rich in mast cells.

6. In vivo and in vitro toxicity of nanogold conjugated snake venom protein toxin GNP-NKCT1.